Acidaminococcus intestini

(aka Acidaminococcus sp. D21)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Acidaminococcus intestini, (aka Acidaminococcus sp. D21), is a Gram-negative, non-spore-forming, anaerobic, non-motile, coccus bacterium. It has been detected in at least 20 gut microbiome compilation studies or metastudies. The DNA G+C content is 49.3%. Acidaminococcus intestini is a common gut coloniser. (JumasBilak2007)



  • This organism has been recovered from clinical sources, and is a normal commensal of the human gut. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a rare opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (JumasBilak2007);
    Character Response
  • Active enzymes:
  • Arg arylamidase; Gly arylamidase; His arylamidase; Leu-Gly arylamidase; pyroGlu arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • Leu arylamidase; pyrrolidine arylamidase;
    • SPECIAL FEATURES (JumasBilak2007);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; butyrate; lactate (minor); indole (strain-dependent);
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (JumasBilak2007);
    Class Active Resistant
  • Penicillins:
  • imipenem;
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • bile; colistin;

  • N/A

  • It has been occasionally related to infective processes but always associated with polymicrobial infections and might act as a reservoir of antibiotic resistance mechanisms. Involved in degradation of amino acids. [PMID: 22123762]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Acidaminococcus intestini (strain RyC-MR95) is a anaerobic Gram-negative bacterium isolated from perianal abscess of a diabetic patient. A.intestini belongs to the class Negativicutes, phylum Firmicutes. Negativicutes show the double-membrane system of Gram-negative bacteria, although their chromosomal backbone is closely related to that of Gram-positive bacteria of the phylum Firmicutes. A. intestini is known to be a normal commensal of the human gut, representing 1% of the fecal bacterial population. It has been occasionally related to infective processes but always associated with polymicrobial infections and might act as a reservoir of antibiotic resistance mechanisms. (Adapted from PMID: 22123762). [UP000007093]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Negativicutes Order:  Acidaminococcales Family:  Acidaminococcaceae Genus:  Acidaminococcus Alt. name:  Acidaminococcus sp. D21 Gram stain:  neg O2 Relation.:  anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccus Pigment:  neg
    Health:  Unknown
    Source:  clinical sources, and is a normal commensal of the human gut
    DNA G+C(%):  49.3
    		Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Mannose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg ArgAA:  + GluGluAA:  neg GlyAA:  + HisAA:  + LeuAA:  d LeuGlyAA:  d(+) PyrrolidAA:  d PyrogluAA:  + AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Amino Acids

    Acetate, Lactate, Propionate, Butyrate

    		Acetate:  + Propionate:  + Butyrate:  + Lactate:  minor(+) Indole:  (d) Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    imipenem:  Sens
    kanamycin:  S(1000; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  R(5; disc)
    metronidazole:  S(4; disc)
    colistin:  S(10; disc)
    Bile:  S(d(+))

    References

    SPECIFIC REFERENCES FOR ACIDAMINOCOCCUS INTESTINI
  • JumasBilak2007 - Acidaminococcus intestini sp. nov., isolated from human clinical samples.
  • DAuria2011 - Complete genome sequence of Acidaminococcus intestini RYC-MR95, a Gram-negative bacterium from the phylum Firmicutes.
  • Feng2015 - Gut microbiome development along the colorectal adenoma-carcinoma sequence
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ACIDAMINOCOCCUS INTESTINI
  • Almeida2019 - A new genomic blueprint of the human gut microbiota.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chung2016 - Modulation of the human gut microbiota by dietary fibres occurs at the species level.
  • Chung2019 - Impact of carbohydrate substrate complexity on the diversity of the human colonic microbiota.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR ACIDAMINOCOCCUS INTESTINI
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021