Adlercreutzia equolifaciens

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Adlercreutzia equolifaciens is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 15 gut microbiome compilation studies or metastudies. The DNA G+C content is 64%. Adlercreutzia equolifaciens is a common gut coloniser. (Maruo2008)



  • This organism has been recovered from human faeces (Alkhalil2017), human and rat intestine. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • QUIRKS
  • Produces equol (an isoflavandiol aestrogen) from isoflavones.
    • GENERAL CHARACTERISTICS (Maruo2008);
    Character Response
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • ⥅
  • Substrates assimilated or utilised:
  • arginine;
  • Active enzymes:
  • Arg arylamidase; arginine dihydrolase; Leu arylamidase;
    • SPECIAL FEATURES (Maruo2008);
    Character Response
  • ✗
  • Nitrate:
  • not reduced

  • N/A

  • This organism metabolizes diadzeins (soybean isoflavonoids) to equol, a nonsteroidal estrogen [PMID: 24051320]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Isolated from the feces of a healthy human and is able to metabolize daidzeins to equol. [PMID: 24051320]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Coriobacteriia Order:  Eggerthellales Family:  Eggerthellaceae Genus:  Adlercreutzia Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:   Positive
    Source:  human faeces (Alkhalil2017), human and rat intestine
    DNA G+C(%):  64
    Bile reaction(%):  20(neg)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arg:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    β-Glucosidase:  neg ArgDH:  + ArgAA:  + LeuAA:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Equol

    References

    SPECIFIC REFERENCES FOR ADLERCREUTZIA EQUOLIFACIENS
  • Maruo2008 - Adlercreutzia equolifaciens gen. nov., sp. nov., an equol-producing bacterium isolated from human faeces, and emended description of the genus Eggerthella.
  • Bajer2017 - Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis
  • Malham2019 - The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease
  • Ventura2019 - Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course
  • Laue2020 - Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ADLERCREUTZIA EQUOLIFACIENS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
  • ...............................
    • GENERAL REFERENCES FOR ADLERCREUTZIA EQUOLIFACIENS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: February 08, 2021