Agathobaculum desmolans

(aka Eubacterium desmolans)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Agathobaculum desmolans, (aka Eubacterium desmolans), is a Gram-positive, non-spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 48.5%. Agathobaculum desmolans is probably a common, although minor, coloniser of the gut. (Ahn2016; Morris1986)



  • This organism has been recovered from human faeces and cat faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • In 39% of Europeans (unseenbio.com). Minor coloniser.
    • GENERAL CHARACTERISTICS (Ahn2016); (Morris1986);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 🧂
  • Salt tolerance:
  • tolerates 1% salt; Grows optimally with 0% salt.
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • pH
  • Acidity tolerance:
  • tolerates pH 6.0-8.0; Grows optimally at pH 7.
  • 🌡
  • Temperature tolerance:
  • grows at 35-40℃; Grows optimally at 37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • L-arabinose; cellubiose; glucose; inositol; lactose; maltose; mannitol; mannose; melezitose; rhamnose; salicin; sucrose; trehalose; xylose;
    • SPECIAL FEATURES (Ahn2016); (Morris1986);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; lactate (trace); succinate (trace); indole;
  • ✗
  • Metabolites not produced:
  • H₂S; H₂;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Morris1986);
    Class Active Resistant
  • Penicillins:
  • aztreonam; penicillin G;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Heterocycles:
  • chloramphenicol;
  • metronidazole;
  • Miscellaneous antibiotics:
  • clindamycin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Eubacteriaceae Genus:  Agathobaculum Alt. name:  Eubacterium desmolans Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and cat faeces
    DNA G+C(%):  48.5
    Opt. T:  37℃
    Mid T(℃):  35-40(+)
    NaCl 0.5-2%:  1(+)
    Opt. pH:  7
    pH 6.0-8.0:  6.0-8.0(+)
    Bile reaction(%):  20(+)
    		Aesculin:  + Gelatin:  neg Starch:  neg Milk:  neg Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Amygdalin:  neg Aesculin:  neg Glycogen:  neg Starch:  neg Pectin:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  + Glucose:  + Mannose:  + Rhamnose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  + Melibiose:  neg Raffinose:  neg Sucrose:  + Trehalose:  + Glycerol:  neg Inositol:  + Mannitol:  + Pectin:  neg Salicin:  + Sorbitol:  neg Trp:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + Lactate:  trace(+) Succinate:  trace(+) H2S:  neg H2:  neg Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    aztreonam:  Res
    penicillin_G:  R(2U)
    erythromycin:  S(3)
    ciprofloxacin:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(6)
    chloramphenicol:  S(12)
    metronidazole:  Res
    clindamycin:  S(1.6)

    References

    SPECIFIC REFERENCES FOR AGATHOBACULUM DESMOLANS
  • Ahn2016 - Agathobaculum butyriciproducens gen. nov., sp. nov., a strict anaerobic, butyrate-producing gut bacterium isolated from human faeces and reclassification of Eubacterium desmolans as Agathobaculum desmolans comb. nov.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Takahashi2016 - Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease
  • Morris1986 - Eubacterium desmolans sp. nov., a Steroid Desmolase-Producing Species from Cat Fecal Flora.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR AGATHOBACULUM DESMOLANS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Mangin2004 - Molecular inventory of faecal microflora in patients with Crohn's disease.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR AGATHOBACULUM DESMOLANS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021