Aggregatibacter segnis

(aka Haemophilus segnis)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Aggregatibacter segnis, (aka Haemophilus segnis), is a Gram-negative, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 11 gut microbiome compilation studies or metastudies. The DNA G+C content is 43-44%. Aggregatibacter segnis is probably a common, although minor, coloniser of the gut. (NorskovLauritsen2006; Kilian1976; Kilian2005Bergey)



  • This organism has been recovered from the appendix (CCUG), pharynx, saliva and dental plaque. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Can cause opportunistic infections, particularly in immunocompromised people. It's gut microbiome symbiotic status is unknown.
    • GENERAL CHARACTERISTICS (NorskovLauritsen2006); (Kilian1976); (Kilian2005Bergey);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; sucrose;
  • Active enzymes:
  • alkaline phosphatase; β-galactosidase;
    • SPECIAL FEATURES (NorskovLauritsen2006); (Kilian1976); (Kilian2005Bergey);
    Character Response
  • ✗
  • Metabolites not produced:
  • H₂S; indole;
  • ±
  • ONPG test:
  • strain dependent
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
  • ±
  • Nitrite:
  • strain dependent

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Pasteurellales Family:  Pasteurellaceae Genus:  Aggregatibacter Alt. name:  Haemophilus segnis Gram stain:  neg O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  the appendix (CCUG), pharynx, saliva and dental plaque
    DNA G+C(%):  43-44
    		Urea:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg L-Arabinose:  neg Fructose:  w Galactose:  w Glucose:  w(+) Rhamnose:  neg Sorbose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  w Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  neg Aesculin:  neg Inulin:  neg Adonitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  w Urease:  neg Haemaggl.:  neg α-Fucosidase:  neg β-Galactosidase:  + α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg β-Mannosidase:  neg Xylosidase:  neg LysDC:  neg OrnDC:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg

    References

    SPECIFIC REFERENCES FOR AGGREGATIBACTER SEGNIS
  • NorskovLauritsen2006 - Reclassification of Actinobacillus actinomycetemcomitans, Haemophilus aphrophilus, Haemophilus paraphrophilus and Haemophilus segnis as Aggregatibacter actinomycetemcomitans gen. nov., comb. nov., Aggregatibacter aphrophilus comb. nov. and Aggregatibacter segnis comb. nov., and emended description of Aggregatibacter aphrophilus to include V factor-dependent and V factor-independent isolates.
  • Kilian1976 - A Taxonomic Study of the Genus Haemophilus, with the Proposal of a New Species.
  • Kilian2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Gammaproteobacteria Part B. Family Pasteurellaceae, Genus III. Haemophilus
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR AGGREGATIBACTER SEGNIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR AGGREGATIBACTER SEGNIS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: July 12, 2021