Alistipes inops

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Alistipes inops is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 56.6%. Alistipes inops is probably a rare gut coloniser. (Shkoporov2015)



  • This organism has been recovered from human faeces (Shkoporov2015). Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Shkoporov2015);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • Active enzymes:
  • Ala arylamidase; glutamic acid decarboxylase; Glu-Glu arylamidase; Leu-Gly arylamidase;
    • SPECIAL FEATURES (Shkoporov2015);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate (minor); succinate; indole;
  • Haemolysis:
  • present but weak
  • ✗
  • Nitrate:
  • not reduced
  • Pigments:
  • weakly produced
    • RESPONSE TO ANTIBIOTICS (Shkoporov2015);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; cloxacillin; oxacillin; penicillin G;
  • ampicillin;
  • Cephalosporins:
  • ceftazidime; cephalothin;
  • cefoperazone; cefoxitin; cefuroxime;
  • Macrolides:
  • roxithromycin;
  • azithromycin;
  • Tetracyclines:
  • deoxycycline;
  • Quinolines:
  • levofloxacin; moxifloxacin;
  • ciprofloxacin;
  • Aminoglycosides:
  • amikacin; gentamicin; neomycin;
  • Heterocycles:
  • fusidic-acid; metronidazole;
  • chloramphenicol; co-trimoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid;
  • NOTES

    Acid
    production is negative from all carbohydrate substrates
    tested.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Rikenellaceae Genus:  Alistipes Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  w
    Health:  Unknown
    Source:  human faeces (Shkoporov2015)
    DNA G+C(%):  56.6
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Gelatin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg β-Glucosidase:  neg GluDC:  + AlanineAA:  + GluGluAA:  + LeuGlyAA:  + Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  minor(+) Succinate:  + Indole:  + Pigment:  w
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Sens
    ampicillin:  Res
    cloxacillin:  Sens
    oxacillin:  Sens
    penicillin_G:  Sens
    cefoperazone:  Res
    cefoxitin:  Res
    ceftazidime:  Sens
    cefuroxime:  Res
    cephalothin:  Sens
    amikacin:  Sens
    gentamicin:  Sens
    neomycin:  Sens
    azithromycin:  Res
    roxithromycin:  Sens
    linezolid:  Sens
    ciprofloxacin:  Res
    levofloxacin:  Sens
    moxifloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    deoxycycline:  Res
    vancomycin:  Sens
    chloramphenicol:  Res
    metronidazole:  Sens
    co-trimoxazole:  Res
    clindamycin:  Sens
    fusidic-acid:  Sens

    References

    SPECIFIC REFERENCES FOR ALISTIPES INOPS
  • Parker2020 - The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health.
  • Shkoporov2015 - Alistipes inops sp. nov. and Coprobacter secundus sp. nov., isolated from human faeces.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ALISTIPES INOPS
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
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    • Added: July 12, 2021