Alistipes obesi

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Alistipes obesi is a Gram-negative, non-spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 58.6%. Alistipes obesi is a common gut coloniser. (Hugon2013)



  • This organism has been recovered from human faeces (obese patient). Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • In 97% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Hugon2013);
    Character Response
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 30℃; grows at 37℃; grows at 45℃; Grows optimally at 37℃.
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; N-Ac β-glucosaminidase; catalase; esterase; esterase lipase C8; α-galactosidase; β-galactosidase; Leu-Gly arylamidase;
    • SPECIAL FEATURES (Hugon2013);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Hugon2013);
    Class Active Resistant
  • Penicillins:
  • imipenem;
  • amoxicillin; amoxicillin-clavulanic acid; penicillin G;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin; kanamycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole; nitrofurantoin;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;
  • NOTES

    This is a recently discovered inhabitant of the human gut.

    Fuel sources used:
    It can use simple sugars and protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, BCAAs, butyrate, GABA, lactate, LPS, propionate, succinate, folate, biotin, riboflavin, vitamin K.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

  • References: [1] [2]

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Rikenellaceae Genus:  Alistipes Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces (obese patient)
    DNA G+C(%):  58.6
    Opt. T:  37℃
    Lower T(℃):  30(neg)
    Mid T(℃):  37(+)
    High T(℃):  45(+)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Mannose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Urease:  neg G6PDH6PGDH:  neg Ac-β-glcamnd:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  neg β-Glucosidase:  neg ArgDH:  neg AlanineAA:  + ArgAA:  neg GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  + ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg AlkalineP:  + Esterase:  + EstLip(C8):  + Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Simple Sugars, Protein

    None/Unknown

    Branched-Chain AA, Folate, Biotin, Riboflavin, Vitamin K, Acetate, Lactate, Propionate, Butyrate, Succinate, GABA

    None/Unknown

    		 Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Res
    Augmentin:  Res
    penicillin_G:  Res
    imipenem:  Sens
    gentamicin:  Res
    kanamycin:  Res
    erythromycin:  Res
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Res
    vancomycin:  Res
    rifampicin:  Sens
    metronidazole:  Sens
    nitrofurantoin:  Sens
    SXT:  Res
    colistin:  Res

    References

    SPECIFIC REFERENCES FOR ALISTIPES OBESI
  • Hugon2013 - Non contiguous-finished genome sequence and description of Alistipes obesi sp. nov.
  • Parker2020 - The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health.
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Luo2018 - Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ALISTIPES OBESI
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
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    • Added: February 08, 2021