Alkaliphilus transvaalensis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Alkaliphilus transvaalensis is a Gram-positive, spore-forming, strictly anaerobic, motile, rod-shaped - curved bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 36.4%. Alkaliphilus transvaalensis is unlikely to be a gut coloniser. (Takai2001)



  • This organism has been recovered from an ultra-deep gold mine under extreme alkaline conditions. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Requires high pH (minimum 8.5) suggest it is not a gut coloniser
    • GENERAL CHARACTERISTICS (Takai2001);
    Character Response
  • pH
  • Acidity tolerance:
  • tolerates pH 8.5-12.5; Grows optimally at pH 10.
  • 🌡
  • Temperature tolerance:
  • grows at 20℃; grows at 50℃; Grows optimally at 40℃.
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  • Substrates assimilated or utilised:
  • fumarate; malate; succinate; D-tartrate; L-tartrate; butanol;
    • SPECIAL FEATURES
    Character Response
  • ✓
  • Thiosulfate:
  • reduced

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Alkaliphilus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod - curved
    Health:  Unknown
    Source:  an ultra-deep gold mine under extreme alkaline conditions
    DNA G+C(%):  36.4
    Opt. T:  40℃
    Lower T(℃):  20(+)
    High T(℃):  50(+)
    Opt. pH:  10
    pH >8:  8.5-12.5(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fumarate:  + Malate:  + Succinate:  + D-Tartrate:  + L-Tartrate:  +

    References

    SPECIFIC REFERENCES FOR ALKALIPHILUS TRANSVAALENSIS
  • Takai2001 - Alkaliphilus transvaalensis gen. nov., sp. nov., an extremely alkaliphilic bacterium isolated from a deep South African gold mine.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ALKALIPHILUS TRANSVAALENSIS
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
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    • Added: October 10, 2022