Amedibacterium intestinale

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Amedibacterium intestinale is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 33.9%. Amedibacterium intestinale is probably a rare gut coloniser. (Ikeyama2020)



  • This organism has been recovered from human faeces (Ikeyama2020). Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Ikeyama2020);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 🧂
  • Salt tolerance:
  • tolerates 0.3% salt; tolerates 2.3% salt; Grows optimally with 1.0% salt.
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • pH
  • Acidity tolerance:
  • tolerates pH 6.2-8.0; Grows optimally at pH 7.
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 37℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; cellubiose; maltose; trehalose; salicin;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; N-Ac β-glucosaminidase; esterase; esterase lipase C8; naphthol-ASBI-P;
    • SPECIAL FEATURES (Ikeyama2020);
    Character Response
  • ✓
  • Metabolites produced:
  • butyrate; lactate (major); H₂S;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Penicillins:
  • amoxicillin; penicillin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • oxytetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin; kanamycin; neomycin; streptomycin;
  • Polypep/ketides:
  • bacitracin;
  • Heterocycles:
  • chloramphenicol;
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Erysipelotrichia Order:  Erysipelotrichales Family:  Erysipelotrichaceae Genus:  Amedibacterium Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  neg
    Health:  Unknown
    Source:  human faeces (Ikeyama2020)
    DNA G+C(%):  33.9
    Opt. T:  37℃
    Lower T(℃):  30(+)
    Mid T(℃):  37(+)
    NaCl 0.5-2%:  0.3(+)
    NaCl 3-5%:  2.3(+)
    Opt. pH:  7
    pH 6.0-8.0:  6.2-8.0(+)
    Bile reaction(%):  20(+)
    		Aesculin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  neg Cellubiose:  + Lactose:  neg Maltose:  + Melezitose:  neg Sucrose:  neg Trehalose:  + Glycerol:  neg Sorbitol:  neg Salicin:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  vr β-Glucosidase:  vr β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg ArgAA:  vr GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  neg PheAA:  neg SerAA:  neg TyrAA:  neg AlkalineP:  + AcidP:  + Esterase:  + EstLip(C8):  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Butyrate:  + Lactate:  Major(+) H2S:  + Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Sens
    penicillin:  S(vr)
    gentamicin:  Res
    kanamycin:  Res
    neomycin:  Res
    streptomycin:  R(vr)
    erythromycin:  R(15; disc, variable)
    ciprofloxacin:  R(5; disc, variable)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    oxytetracycline:  S(30; disc, variable)
    vancomycin:  Sens
    bacitracin:  S(10U)
    chloramphenicol:  Sens
    SXT:  Res
    colistin:  Sens

    References

    SPECIFIC REFERENCES FOR AMEDIBACTERIUM INTESTINALE
  • Ikeyama2020 - Amedibacterium intestinale gen. nov., sp. nov., isolated from human faeces, and reclassification of Eubacterium dolichum Moore et al. 1976 (Approved Lists 1980) as Amedibacillus dolichus gen. nov., comb. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR AMEDIBACTERIUM INTESTINALE
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • ...............................
    • GENERAL REFERENCES FOR AMEDIBACTERIUM INTESTINALE
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: July 17, 2021