Amycolatopsis alba

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Amycolatopsis alba is a Gram-positive, exosporous, aerobic, non-motile, filamentous bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. Amycolatopsis alba is probably a rare gut coloniser. (Mertz1993)



  • This organism has been recovered from soil. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • Produces a new glycopeptide antibiotic related to vancomycin.
    • GENERAL CHARACTERISTICS (Mertz1993);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; casein; gelatin; hippurate; starch; tyrosine; urea; xanthine;
  • 🧂
  • Salt tolerance:
  • tolerates 5% salt;
  • 🌡
  • Temperature tolerance:
  • grows at 15℃; grows at 37℃; doesn't grow at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • D-arabinose; L-arabinose; fructose; galactose; glucose; mannose; ribose; xylose; cellubiose; lactose; maltose; melibiose; raffinose; trehalose; adonitol; erythritol; glycerol; inositol; α-methyl glucoside; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • fructose; galactose; glucose; inositol; mannitol; raffinose; salicin; xylose; acetate; butyrate; citrate; formate; lactate; malate; propionate; pyruvate; succinate;
  • Active enzymes:
  • catalase; urease;
    • SPECIAL FEATURES (Mertz1993);
    Character Response
  • ✓
  • Metabolites produced:
  • H₂S;
  • Lysozyme:
  • growth observed
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Mertz1993);
    Class Active Resistant
  • Penicillins:
  • penicillin;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • oleandomycin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • gentamicin; streptomycin; tobramycin;
  • neomycin;
  • Polypep/ketides:
  • bacitracin; rifampicin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • lincomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinobacteria Order:  Pseudonocardiales Family:  Pseudonocardiaceae Genus:  Amycolatopsis Gram stain:  + O2 Relation.:  aerobic Spore:  Exospore Motility:  Sessile Morphology:  Filamentous
    Health:  Unknown
    Source:  soil
    Low T(℃):  15(+)
    Mid T(℃):  37(+)
    High T(℃):  45(neg)
    NaCl 3-5%:  5(+)
    		Aesculin:  + Urea:  + Gelatin:  + Starch:  + Casein:  + Tyrosine:  + Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  + L-Arabinose:  + Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  + Sorbose:  neg Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  + Sucrose:  neg Trehalose:  + Cellulose:  neg Dextrin:  neg Glycogen:  neg Inulin:  neg Adonitol:  + Dulcitol:  neg Erythritol:  + Glycerol:  + Inositol:  + Sorbitol:  neg Xylitol:  neg Ethanol:  neg Me-α-D-Glc:  + Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Rhamnose:  neg Xylose:  + Raffinose:  + Sucrose:  neg Inositol:  + Mannitol:  + Salicin:  + Acetate:  + Benzoate:  neg Butyrate:  + Citrate:  + Formate:  + Lactate:  + Malate:  + Mucate:  neg Propionate:  + Pyruvate:  + Succinate:  + D-Tartrate:  neg L-Tartrate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  S(10U)
    cephalothin:  S(30; disc)
    gentamicin:  S(10; disc)
    neomycin:  R(30; disc)
    streptomycin:  S(10; disc)
    tobramycin:  S(10; disc)
    oleandomycin:  R(15; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  R(30; disc)
    vancomycin:  S(30; disc)
    bacitracin:  R(10U)
    rifampicin:  R(5; disc)
    lincomycin:  S(2; disc)

    References

    SPECIFIC REFERENCES FOR AMYCOLATOPSIS ALBA
  • Mertz1993 - Amycolatopsis alba sp. nov., isolated from soil.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR AMYCOLATOPSIS ALBA
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
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    • Added: May 15, 2022