Anaerobiospirillum succiniciproducens

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Anaerobiospirillum succiniciproducens is a Gram-negative, non-spore-forming, strictly anaerobic, motile, spirochete bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 44%. Anaerobiospirillum succiniciproducens is probably a rare gut coloniser. (Davis1976; Malnick1997; Morotomi2010; Malnick2005Bergey)



  • This organism has been recovered from human faeces, clinical sources (blood - CCUG) and animals. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a rare opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Davis1976); (Kelesidis2010); (Malnick1997); (Morotomi2010); (Malnick2005Bergey);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 18℃; grows at 25℃; grows at 40℃; doesn't grow at 41℃; Grows optimally at 37-40℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; inulin; lactose; raffinose; sucrose;
  • Active enzymes:
  • N-Ac β-glucosaminidase; β-galactosidase; α-glucosidase; Gly arylamidase; Leu arylamidase;
    • SPECIAL FEATURES (Davis1976); (Morotomi2010); (Malnick2005Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; lactate (minor); succinate;
  • ✗
  • Metabolites not produced:
  • indole;
  • Haemolysis:
  • beta (weak)
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Kelesidis2010); (Malnick2005Bergey); (Goldstein2006c); (Goldstein1999b);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; imipenem; meropenem; penicillin G; piperacillin-tazobactam;
  • mezlocillin;
  • Cephalosporins:
  • cefotaxime; cefoxitin; cephalothin;
  • cefalexin;
  • Macrolides:
  • azithromycin;
  • roxithromycin;
  • Tetracyclines:
  • doxycycline; tigecycline;
  • Quinolines:
  • ciprofloxacin; gemifloxacin; levofloxacin; moxifloxacin; trovafloxacin;
  • nalidixic-acid;
  • Heterocycles:
  • chloramphenicol; trimethoprim;
  • sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; daptomycin; lincomycin; polymyxin B;

  • Anaerobiospirillum succiniciproducens is a rare cause of bacteraemia in humans.

  • Malnick, H. (1997). Anaerobiospirillum thomasii sp. nov., an anaerobic spiral bacterium isolated from the feces of cats and dogs and from diarrheal feces of humans, and emendation of the genus Anaerobiospirillum. International Journal of Systematic Bacteriology, 47(2), 381–384.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Gammaproteobacteria Order:  Aeromonadales Family:  Succinivibrionaceae Genus:  Anaerobiospirillum Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Swimming Morphology:  Spirochete
    Health:  Unknown
    Source:  human faeces, clinical sources (blood - CCUG) and animals
    DNA G+C(%):  44
    Opt. T:  37-40℃
    Low T(℃):  18(neg)
    Lower T(℃):  25(+)
    Mid T(℃):  40(+)
    High T(℃):  41(neg)
    		Aesculin:  neg Urea:  neg Gelatin:  neg Starch:  vr Hippurate:  neg Milk:  curdle(vr) Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  + Galactose:  neg Glucose:  + Mannose:  neg Rhamnose:  neg Xylose:  neg Cellubiose:  neg Lactose:  + Maltose:  vr Melibiose:  vr Sucrose:  + Trehalose:  vr Aesculin:  neg Inulin:  + Adonitol:  neg Dulcitol:  neg Glycerol:  vr Inositol:  vr Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  + LeuAA:  + LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Lactate:  minor(+) Succinate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.125–0.5)
    ampicillin:  Var
    mezlocillin:  Res
    penicillin_G:  S(MIC50): 0.06, MIC90: 0.5, RNG: (0.06–1)
    piper-taz:  S(MIC50): 0.125, MIC90: 4, RNG: (0.03–4)
    imipenem:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.06–0.125)
    meropenem:  S(MIC50): 0.03, MIC90: 0.03, RNG: (0.015–0.03)
    cefalexin:  Res
    cefotaxime:  S(MIC50): ≤0.015, MIC90: 0.06, RNG: (≤0.015–0.06)
    cefoxitin:  Sens
    cephalothin:  Sens
    azithromycin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.125–1)
    erythromycin:  Var(MIC50): 4, MIC90: 16, RNG: (1–16)
    clarithromycin:  Var(MIC50): 4, MIC90: 32, RNG: (2–32)
    roxithromycin:  R(MIC50): 16, MIC90: >32, RNG: (4–>32)
    telithromycin:  Var(MIC50): 2, MIC90: 8, RNG: (0.5–8)
    ciprofloxacin:  Sens
    gemifloxacin:  S(MIC50): 1, MIC90: -, RNG: (0.5–2)
    levofloxacin:  S(≤0.5)
    moxifloxacin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.06–1)
    nalidixic-acid:  Res
    trovafloxacin:  S(MIC50): 0.125, MIC90: 1, RNG: (0.06–2)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125–0.5)
    tigecycline:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.06–0.25)
    vancomycin:  Res
    chloramphenicol:  Sens
    metronidazole:  Var(MIC50): 4, MIC90: 8, RNG: (1–8)
    sulfamethoxazole:  Res
    trimethoprim:  S(4)
    clindamycin:  R(MIC50): 32, MIC90: >32, RNG: (8–>32)
    lincomycin:  Res
    daptomycin:  R(>256)
    polymyxin_B:  Res

    References

    SPECIFIC REFERENCES FOR ANAEROBIOSPIRILLUM SUCCINICIPRODUCENS
  • Davis1976 - Anaerobiospirillum, a New Genus of Spiral-Shaped Bacteria.
  • Kelesidis2010 - First Report of Treatment of Anaerobiospirillum succiniciproducens Bloodstream Infection with Levofloxacin.
  • Malnick1997 - Anaerobiospirillum thomasii sp. nov., an Anaerobic Spiral Bacterium Isolated from the Feces of Cats and Dogs and from Diarrheal Feces of Humans, and Emendation of the Genus Anaerobiospirillum.
  • Morotomi2010 - Succinatimonas hippei gen. nov., sp. nov., isolated from human faeces.
  • Malnick2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Gammaproteobacteria Part B. Family Succinivibrionaceae, Genus II. Anaerobiospirillum
  • Goldstein2006c - Comparative in vitro susceptibilities of 396 unusual anaerobic strains to tigecycline and eight other antimicrobial agents.
  • Goldstein1999b - Activities of telithromycin (HMR 3647, RU 66647) compared to those of erythromycin, azithromycin, clarithromycin, roxithromycin, and other antimicrobial agents against unusual anaerobes.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ANAEROBIOSPIRILLUM SUCCINICIPRODUCENS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
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    • Added: April 08, 2021