Anaerococcus octavius

(aka Peptostreptococcus octavius)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Anaerococcus octavius, (aka Peptostreptococcus octavius), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, streptococci bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 26-31%. Anaerococcus octavius is probably a rare gut coloniser. (Ezaki2001; Murdoch1997; Ezaki2011cBergey)



  • This organism has been recovered from human faeces and clinical specimens (nasal, vagina, blood, skin). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Can cause opportunistic infections, particularly in immunocompromised people. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Ezaki2001); (Murdoch1997); (Ezaki2011cBergey);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; mannose; ribose;
  • Active enzymes:
  • Pro arylamidase; pyroGlu arylamidase; pyrrolidine arylamidase;
    • SPECIAL FEATURES (Ezaki2001); (Murdoch1997); (Ezaki2011cBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate (major); lactate; valerate; caproate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Tyrrell2012);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; ertapenem; imipenem; meropenem; penicillin G; piperacillin-tazobactam;
  • Cephalosporins:
  • cefotetan; cefoxitin;
  • Tetracyclines:
  • doxycycline; tigecycline;
  • Quinolines:
  • moxifloxacin;
  • levofloxacin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; daptomycin; linezolid;

  • Dubourg, G., Lagier, J. C., Armougom, F., Robert, C., Hamad, I., Brouqui, P., & Raoult, D. (2013). The gut microbiota of a patient with resistant tuberculosis is more comprehensively studied by culturomics than by metagenomics. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology, 32(5), 637–645.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Tissierellia Order:  Tissierellales Family:  Peptoniphilaceae Genus:  Anaerococcus Alt. name:  Peptostreptococcus octavius Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Streptococci
    Health:  Unknown
    Source:  human faeces and clinical specimens (nasal, vagina, blood, skin)
    DNA G+C(%):  26-31
    Opt. T:  37℃
    		Aesculin:  neg Urea:  neg Gelatin:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg L-Arabinose:  neg Fructose:  + Glucose:  + Mannose:  + Ribose:  + D-Tagatose:  neg Xylose:  neg Cellubiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Sucrose:  neg Trehalose:  neg Dextrin:  neg Glycogen:  neg D-Arabitol:  neg Mannitol:  neg Sorbitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  vr Urease:  neg Coagulase:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg β-Mannosidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg AlaPheProAA:  neg ArgAA:  neg GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  neg ProAA:  + PyrrolidAA:  + PyrogluAA:  + TyrAA:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  neg EstLip(C8):  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  Major(+) Lactate:  + Valerate:  + Caproate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(≤0.06/0.25)
    ampicillin:  S(MIC50): 0.03, MIC90: 0.25, RNG: (0.03–>8)
    penicillin_G:  Sens
    piper-taz:  S(MIC50): 0.03, MIC90: 0.5, RNG: (0.03–16)
    ertapenem:  S(0.06/0.25)
    imipenem:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–2)
    meropenem:  Sens
    cefotetan:  Sens
    cefoxitin:  Sens
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–2)
    levofloxacin:  Res
    moxifloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Sens
    tigecycline:  S(0.064)
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.06–1)
    chloramphenicol:  Sens
    metronidazole:  S(MIC50): 0.25, MIC90: 1, RNG: (0.03–2)
    clindamycin:  Sens
    daptomycin:  S(MIC50): 0.125, MIC90: 0.5, RNG: (0.03–1)

    References

    SPECIFIC REFERENCES FOR ANAEROCOCCUS OCTAVIUS
  • Ezaki2001 - Proposal of the genera Anaerococcus gen. nov., Peptoniphilus gen. nov. and Gallicola gen. nov. for members of the genus Peptostreptococcus.
  • Murdoch1997 - Description of Three New Species of the Genus Peptostreptococcus from Human Clinical Specimens: Peptostreptococcus harei sp. nov., Peptostreptococcus ivorii sp. nov., and Peptostreptococcus octavius sp. nov.
  • Ezaki2011cBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Incertae Sedis, Genus I. Anaerococcus
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ANAEROCOCCUS OCTAVIUS
  • Aujoulat2014 - Temporal dynamics of the very premature infant gut dominant microbiota.
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Dubourg2013 - The gut microbiota of a patient with resistant tuberculosis is more comprehensively studied by culturomics than by metagenomics.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR ANAEROCOCCUS OCTAVIUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021