Anaerococcus tetradius

(aka Peptostreptococcus tetradius)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Anaerococcus tetradius, (aka Peptostreptococcus tetradius), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, tetrad bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 30-32%. Anaerococcus tetradius is probably a rare gut coloniser. (Ezaki1983; Ezaki2001)



  • This organism has been recovered from vaginal discharges and ovarian abscesses. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Ezaki1983); (Ezaki2001);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose;
  • Active enzymes:
  • Arg arylamidase; α-glucosidase; β-glucosidase; Leu arylamidase; urease;
    • SPECIAL FEATURES (Ezaki1983); (Ezaki2001);
    Character Response
  • ✓
  • Metabolites produced:
  • butyrate;
  • ✗
  • Metabolites not produced:
  • indole;
    • RESPONSE TO ANTIBIOTICS (Tyrrell2012); (Goldstein2008); (Goldstein2006a); (Goldstein2006b); (Goldstein2000); (Goldstein2000a);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; ampicillin; ampicillin-sulbactam; doripenem; ertapenem; imipenem; meropenem; penicillin; penicillin G; piperacillin-tazobactam; ticarcillin-clavulanic acid;
  • Cephalosporins:
  • cefepime; cefotaxime; cefotetan; cefoxitin;
  • Macrolides:
  • erythromycin; quinupristin-dalfopristin;
  • Tetracyclines:
  • doxycycline; minocycline;
  • Quinolines:
  • gatifloxacin; moxifloxacin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • Vancomycins:
  • vancomycin; dalbavancin; teicoplanin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid; ranbezolid;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Tissierellia Order:  Tissierellales Family:  Peptoniphilaceae Genus:  Anaerococcus Alt. name:  Peptostreptococcus tetradius Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Tetrad
    Health:  Unknown
    Source:  vaginal discharges and ovarian abscesses
    DNA G+C(%):  30-32
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  d(+) Mannose:  + Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Cellulose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  + Coagulase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  + β-Glucosidase:  + ArgDH:  neg ArgAA:  + HisAA:  w LeuAA:  + ProAA:  neg PheAA:  w PyrogluAA:  w AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Butyrate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(MIC50): ≤0.125, MIC90: ≤0.5, RNG: (≤0.125-32)
    Augmentin:  S(MIC50): ≤0.125, MIC90: ≤0.5, RNG: (≤0.125-32)
    ampicillin:  S(MIC50): 0.03, MIC90: 0.25, RNG: (0.03–>8)
    amp-sulb:  S(MIC50): 0.06, MIC90: 0.5, RNG: (0.06–8)
    penicillin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–0.5)
    penicillin_G:  S(MIC50): 0.125, MIC90: 0.25, RNG: (≤0.015–1)
    piper-taz:  S(MIC50): 0.03, MIC90: 0.25, RNG: (0.03–0.5)
    tica-clav:  S(MIC50): 0.5, MIC90: 16, RNG: (0.06–128)
    doripenem:  S(MIC50): 0.015, MIC90: 0.06, RNG: (0.015–0.5)
    ertapenem:  S(0.06/0.25)
    imipenem:  S(MIC50): ≤0.06, MIC90: 0.125, RNG: (≤0.016-2)
    meropenem:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–0.25)
    cefepime:  S(MIC50): 0.5, MIC90: 4, RNG: (0.25–8)
    cefotaxime:  S(MIC50): 0.25, MIC90: 2, RNG: (0.06–2)
    cefotetan:  S(MIC50): 0.25, MIC90: 2, RNG: (0.03–8)
    cefoxitin:  S(MIC50): 1, MIC90: 8, RNG: (0.06–8)
    ceftazidime:  Var(MIC50): 4, MIC90: 16, RNG: (0.25–32)
    azithromycin:  Var(MIC50): 0.5, MIC90: >32, RNG: (0.25–>32)
    erythromycin:  S(MIC50): 0.25, MIC90: 0.128, RNG: (0.06–.128)
    quin-dalf:  S(MIC50): 0.5, MIC90: 0.5, RNG: (0.25-0.5)
    linezolid:  S(MIC50): 1, MIC90: 2, RNG: (0.5-2)
    gatifloxacin:  S(MIC50): 0.5, MIC90: 2, RNG: (0.125-16.0)
    levofloxacin:  Var(MIC50): 2, MIC90: >8, RNG: (0.125–>8)
    moxifloxacin:  S(MIC50): 0.25, MIC90: 2, RNG: (0.06-16.0)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 4, RNG: (0.06–16)
    minocycline:  S(MIC50): 0.125, MIC90: 8, RNG: (0.03–8)
    tetracycline:  Var(MIC50): 0.5, MIC90: 16, RNG: (0.125–32)
    dalbavancin:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.015–0.25)
    teicoplanin:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.006-0.25)
    vancomycin:  S(MIC50): 0.5, MIC90: 1, RNG: (0.125-1.0)
    chloramphenicol:  S(MIC50): 2, MIC90: 4, RNG: (1–8)
    metronidazole:  S(MIC50): 0.5, MIC90: 2, RNG: (≤0.125-2)
    ranbezolid:  S(MIC50): 0.008, MIC90: 0.016, RNG: (0.008-0.03)
    clindamycin:  Var(MIC50): 0.06, MIC90: >16, RNG: (0.06->16)
    daptomycin:  S(MIC50): 0.25, MIC90: 1, RNG: (0.03–1)

    References

    SPECIFIC REFERENCES FOR ANAEROCOCCUS TETRADIUS
  • Ezaki1983 - Transfer of Peptococcus indolicus, Peptococcus asaccharolyticus, Peptococcus prevotii, and Peptococcus magnus to the Genus Peptostreptococcus and Proposal of Peptostreptococcus tetradius sp. nov.
  • Ezaki2001 - Proposal of the genera Anaerococcus gen. nov., Peptoniphilus gen. nov. and Gallicola gen. nov. for members of the genus Peptostreptococcus.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Goldstein2008 - In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds.
  • Goldstein2006a - In vitro activity of ceftobiprole against aerobic and anaerobic strains isolated from diabetic foot infections.
  • Goldstein2006b - In vitro activities of dalbavancin and 12 other agents against 329 aerobic and anaerobic gram-positive isolates recovered from diabetic foot infections.
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
  • Goldstein2000a - Comparative In vitro activities of ertapenem (MK-0826) against 1,001 anaerobes isolated from human intra-abdominal infections.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ANAEROCOCCUS TETRADIUS
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    • Added: October 10, 2022