Anaerostipes caccae

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Anaerostipes caccae is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 17 gut microbiome compilation studies or metastudies. The DNA G+C content is 46%. Anaerostipes caccae is a common gut coloniser. (Schwiertz2002; Workneh2016; Editorial2011aBergey)



  • This organism has been recovered from human faeces, and clinical sources (blood - CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Could be a possible pathogen in humans, but unknown at this stage. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Schwiertz2002); (Workneh2016); (Editorial2011aBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; sorbose; D-tagatose; starch; maltose; D-lyxose; melibiose; sucrose; D-turanose; adonitol; D-arabitol; L-arabitol; dulcitol; erythritol; inositol; mannitol; sorbitol; arbutin; α-methyl glucoside; N-Ac glucosamine;
  • ⥅
  • Substrates assimilated or utilised:
  • acetate; DL-lactate; L-lactate;
  • Active enzymes:
  • acid phosphatase; arginine dihydrolase; α-galactosidase; phosphoamidase;
    • SPECIAL FEATURES (Schwiertz2002); (Editorial2011aBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; butyrate; lactate; CO₂; H₂;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • Nitrate:
  • weakly reduced
    • RESPONSE TO ANTIBIOTICS (Workneh2016);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ertapenem; piperacillin-tazobactam;
  • penicillin;
  • Heterocycles:
  • metronidazole;
  • Miscellaneous antibiotics:
  • clindamycin;

  • Schwiertz, A., Hold, G. L., Duncan, S. H., Gruhl, B., Collins, M. D., Lawson, P. A., Flint, H. J., & Blaut, M. (2002). Anaerostipes caccae gen. nov., sp. nov., a new saccharolytic, acetate-utilising, butyrate-producing bacterium from human faeces. Systematic and Applied Microbiology, 25(1), 46–51.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Anaerostipes Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, and clinical sources (blood - CCUG)
    DNA G+C(%):  46
    Mid T(℃):  37(+)
    		Aesculin:  + Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  + D-Fucose:  neg Galactose:  + Glucose:  + Mannose:  + D-Lyxose:  + Rhamnose:  neg Ribose:  w Sorbose:  + D-Tagatose:  + Xylose:  neg L-Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  + Melezitose:  neg Melibiose:  + Sucrose:  + Turanose:  + Amygdalin:  neg Glycogen:  neg Inulin:  neg Starch:  + Adonitol:  + D-Arabitol:  + L-Arabitol:  + Dulcitol:  + Erythritol:  + Inositol:  + Mannitol:  + Sorbitol:  + Arbutin:  + Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  + Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  + Salicin:  w
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Acetate:  + DL-Lactate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  neg Ac-α-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  + Chymotrypsin:  neg Trypsin:  neg AlanineAA:  neg ArgAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg LeuGlyAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  + Esterase(C4):  neg EstLip(C8):  neg Lipase(C14):  neg Phosphoamidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Butyrate:  + Lactate:  + CO2:  + H2:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Sens
    penicillin:  R(>2)
    piper-taz:  Sens
    ertapenem:  S(≤0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    metronidazole:  S(≤2)
    clindamycin:  R(>4)

    References

    SPECIFIC REFERENCES FOR ANAEROSTIPES CACCAE
  • Schwiertz2002 - Anaerostipes caccae gen. nov., sp. nov., a New Saccharolytic, Acetate-utilising, Butyrate-producing Bacterium from Human Faeces.
  • Workneh2016 - Bypass graft infection and bacteremia caused by Anaerostipes caccae: First report of human infection caused by a recently described gut anaerobe.
  • Editorial2011aBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lachnospiraceae, Genus III. Anaerostipes
  • Nylund2015 - Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ANAEROSTIPES CACCAE
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Salonen2014 - Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR ANAEROSTIPES CACCAE
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021