Asaccharospora irregularis

(aka Clostridium irregulare)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Asaccharospora irregularis, (aka Clostridium irregulare), is a Gram-positive, spore-forming, anaerobic, motile, rod-shaped bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. Asaccharospora irregularis is probably a rare gut coloniser. (Gerritsen2014; Rainey2011fBergey)



  • This organism has been recovered from human faeces, lesions, soil and horses. It is an opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Gerritsen2014); (Rainey2011fBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin;
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 6.5% salt;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • 🌡
  • Temperature tolerance:
  • grows weakly at 25℃; doesn't grow at 45℃; Grows optimally at 30-37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • pyruvate;
    • SPECIAL FEATURES (Gerritsen2014); (Rainey2011fBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate; propionate (minor); isobutyrate (minor); isovalerate; Hâ‚‚S;
  • ✗
  • Metabolites not produced:
  • Hâ‚‚; indole;
  • ✗
  • Haemolysis:
  • absent

  • Finegold, S. M., Howard, R. A., & Vera, L. S. (1974). Effect of diet on human intestinal fecal flora: comparison of Japanese and American diets. Am. J. Clin. Nutr, 27, 1456–1469.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Asaccharospora Alt. name:  Clostridium irregulare Gram stain:  + O2 Relation.:  anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, lesions, soil and horses
    Opt. T:  30-37℃
    Lower T(℃):  25(w)
    High T(℃):  45(neg)
    NaCl >6%:  6.5(neg)
    Bile reaction(%):  20(neg)
    		Gelatin:  + Casein:  neg Milk:  neg Meat:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  neg Fructose:  neg Fucose:  neg D-Fucose:  neg Galactose:  neg Glucose:  neg Mannose:  neg D-Lyxose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  neg Xylose:  neg L-Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Turanose:  neg Amygdalin:  neg Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  neg Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Thr:  neg Lactate:  neg Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Lecithinase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  minor(+) Acetate:  + Propionate:  minor(+) Isobutyrate:  minor(+) Isovalerate:  + H2S:  + H2:  neg Indole:  neg

    References

    SPECIFIC REFERENCES FOR ASACCHAROSPORA IRREGULARIS
  • Gerritsen2014 - Characterization of Romboutsia ilealis gen. nov., sp. nov., isolated from the gastro-intestinal tract of a rat, and proposal for the reclassification of five closely related members of the genus Clostridium into the genera Romboutsia gen. nov., Intestinibacter gen. nov., Terrisporobacter gen. nov. and Asaccharospora gen. nov.
  • Rainey2011fBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XI
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR ASACCHAROSPORA IRREGULARIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Finegold1974 - Effect of diet on human fecal flora: comparison of Japanese and American diets
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • PerisBondia2011 - The active human gut microbiota differs from the total microbiota.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • GENERAL REFERENCES FOR ASACCHAROSPORA IRREGULARIS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021