Bacteroides nordii

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Bacteroides nordii is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 15 gut microbiome compilation studies or metastudies. The DNA G+C content is 41.4%. Bacteroides nordii is a common gut coloniser. (Song2004; Song2010Bergeys; Terekhov2018)



  • This organism has been recovered from human faeces, clinical sources (peritoneal fluid - CCUG) and human gut. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a rare opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Song2004); (Song2010Bergeys);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; gelatin;
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; xylose; lactose; maltose; raffinose; sucrose; glycerol;
  • ±
  • Strain-dependent acid from carbs:
  • rhamnose; cellubiose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; acid phosphatase; N-Ac β-glucosaminidase; β-galactosidase; α-glucosidase; β-glucosidase; glutamic acid decarboxylase; Leu-Gly arylamidase; naphthol-ASBI-P;
  • ±
  • Strain-dependent active enzymes:
  • Glu-Glu arylamidase;
    • SPECIAL FEATURES (Song2004); (Song2010Bergeys);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate (major); propionate (minor); isovalerate (minor); indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Song2004); (Song2010Bergeys); (Goldstein2018a); (Goldstein2013b); (Tyrrell2012); (Snydman2008);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin-sulbactam; doripenem; ertapenem; imipenem; meropenem; piperacillin-tazobactam;
  • ampicillin; penicillin G;
  • Cephalosporins:
  • cefotetan; ceftazidime; ceftizoxime;
  • Aminoglycosides:
  • kanamycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; colistin;

  • Song, Y. L., Liu, C. X., McTeague, M., & Finegold, S. M. (2004). “Bacteroides nordii” sp. nov. and “Bacteroides salyersae” sp. nov. isolated from clinical specimens of human intestinal origin. Journal of Clinical Microbiology, 42(12), 5565–5570.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Bacteroidaceae Genus:  Bacteroides Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces, clinical sources (peritoneal fluid - CCUG) and human gut
    DNA G+C(%):  41.4
    Bile reaction(%):  20(+)
    		Aesculin:  + Urea:  neg Gelatin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  d Xylose:  + Cellubiose:  d Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  neg Xylan:  neg Glycerol:  + Mannitol:  neg Sorbitol:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg α-Arab:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  + AlanineAA:  + ArgAA:  neg GluGluAA:  d GlyAA:  neg LeuAA:  neg LeuGlyAA:  + PyrrolidAA:  neg AlkalineP:  + AcidP:  + Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Acetate, Succinate

    		Formate:  minor(+) Acetate:  Major(+) Propionate:  minor(+) Isovalerate:  minor(+) Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(≤8)
    ampicillin:  R(MIC50): >32, MIC90: >32, RNG: (16–>32)
    amp-sulb:  S(MIC50): 4, MIC90: 16, RNG: (2–16)
    penicillin_G:  R(≥32)
    piper-taz:  S(MIC50): 2, MIC90: 8, RNG: (0.06–16)
    doripenem:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)
    ertapenem:  S(MIC50): 1, MIC90: 2, RNG: (0.5–4)
    imipenem:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–2)
    meropenem:  S(MIC50): 0.5, MIC90: 1, RNG: (0.125–32)
    cefotetan:  R(≥64)
    cefoxitin:  Var(MIC50): 16, MIC90: 64, RNG: (4–64)
    ceftazidime:  R(MIC50): >128, MIC90: >128, RNG: (16–>128)
    ceftizoxime:  R(≥32)
    kanamycin:  R(1000; disc)
    linezolid:  Var(MIC50): 4, MIC90: 8, RNG: (2–8)
    moxifloxacin:  Var(MIC50): 2, MIC90: 16, RNG: (0.5–32)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tigecycline:  Var(MIC50): 0.5, MIC90: 8, RNG: (0.125–32)
    vancomycin:  R(MIC50): 64, MIC90: 128, RNG: (32–256)
    metronidazole:  S(MIC50): 2, MIC90: 2, RNG: (0.5–2)
    clindamycin:  Var(MIC50): 2, MIC90: >128, RNG: (0.06–>128)
    daptomycin:  R(MIC50): >32, MIC90: >32, RNG: (>32)
    colistin:  R(10; disc)

    References

    SPECIFIC REFERENCES FOR BACTEROIDES NORDII
  • Song2004 - Bacteroides nordii' sp. nov. and 'Bacteroides salyersae' sp. nov. Isolated from Clinical Specimens of Human Intestinal Origin.
  • Wexler2007 - Bacteroides : the Good, the Bad, and the Nitty-Gritty.
  • Song2010Bergeys - Bacteroides. In Bergey's manual of systematic bacteriology: Vol. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes
  • Terekhov2018 - Ultrahigh-throughput functional profiling of microbiota communities.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • ElMouzan2018 - Microbiota profile in new-onset pediatric Crohn's disease: data from a non-Western population
  • Huang2019a - Metagenome-wide association study of the alterations in the intestinal microbiome composition of ankylosing spondylitis patients and the effect of traditional and herbal treatment
  • Wang2019 - Differential composition of gut microbiota among healthy volunteers, morbidly obese patients and post-bariatric surgery patients
  • Zuo2020 - Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization
  • Goldstein2018a - Comparative In Vitro Activities of Relebactam, Imipenem, the Combination of the Two, and Six Comparator Antimicrobial Agents against 432 Strains of Anaerobic Organisms, Including Imipenem-Resistant Strains.
  • Goldstein2013b - Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Snydman2008 - In vitro activities of doripenem, a new broad-spectrum carbapenem, against recently collected clinical anaerobic isolates, with emphasis on the Bacteroides fragilis group.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BACTEROIDES NORDII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR BACTEROIDES NORDII
  • Song2010Bergeys - Bacteroides. In Bergey's manual of systematic bacteriology: Vol. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes
    • Added: April 08, 2021