Bacteroides pyogenes

(aka Bacteroides tectum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Bacteroides pyogenes, (aka Bacteroides tectum), is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 46.1-47.6%. Bacteroides pyogenes is probably a common, although minor, coloniser of the gut. (Benno1983; Song2010Bergeys)



  • This organism has been recovered from human faeces, clinical sources (blood - CCUG), and pig faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: animal pathogen). Is a rare opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • In 58% of Europeans (unseenbio.com). A minor coloniser.
    • GENERAL CHARACTERISTICS (Benno1983); (Song2010Bergeys);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • aesculin; DNA; starch;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate bile
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 15℃; doesn't grow at 45℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; lactose; glycerol;
  • ±
  • Strain-dependent acid from carbs:
  • amygdalin; glycogen; starch; cellubiose; maltose; melibiose; raffinose; sucrose; sorbitol; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • lactate;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; acid phosphatase; N-Ac β-glucosaminidase; fucosidase; β-galactosidase; α-glucosidase; Glu-Glu arylamidase; Leu-Gly arylamidase;
    • SPECIAL FEATURES (Benno1983); (Song2010Bergeys);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate (trace); succinate; isovalerate (trace); H₂S (variable);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (Benno1983); (Song2010Bergeys); (Goldstein2018); (Goldstein2017); (Goldstein2006c);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; imipenem; meropenem; penicillin; penicillin G; piperacillin-tazobactam;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin; roxithromycin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline; tigecycline;
  • Quinolines:
  • moxifloxacin;
  • Aminoglycosides:
  • kanamycin; neomycin;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid; colistin;
  • polymyxin B;

  • Macfarlane, S., Furrie, E., Cummings, J. H., & Macfarlane, G. T. (2004). Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 38(12), 1690–1699.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Bacteroidaceae Genus:  Bacteroides Alt. name:  Bacteroides tectum Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  neg
    Health:  Unknown
    Source:  human faeces, clinical sources (blood - CCUG), and pig faeces
    DNA G+C(%):  46.1-47.6
    Opt. T:  37℃
    Low T(℃):  15(neg)
    High T(℃):  45(neg)
    Bile reaction(%):  neg
    		Aesculin:  d Urea:  neg Gelatin:  neg Starch:  d Casein:  neg DNA:  d
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Ribose:  w Xylose:  neg Cellubiose:  d Lactose:  + Maltose:  d Melibiose:  d Sucrose:  d Amygdalin:  d Glycogen:  d Starch:  d Xylan:  neg Adonitol:  neg Erythritol:  neg Glycerol:  + Sorbitol:  d Salicin:  d
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Lactate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  vr β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + GluGluAA:  + GlyAA:  neg LeuAA:  neg LeuGlyAA:  + PyrrolidAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  vr EstLip(C8):  vr Lecithinase:  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    Acetate, Succinate

    		Acetate:  + Propionate:  trace(+) Succinate:  + Isovalerate:  trace(+) H2S:  vr Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(MIC50): 0.06, MIC90: 1, RNG: (0.06–1)
    penicillin:  S(MIC50): 0.03, MIC90: 8, RNG: (0.03–8)
    penicillin_G:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.015–4)
    piper-taz:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.03–0.25)
    imipenem:  S(MIC50): 0.06, MIC90: 0.125, RNG: (0.015–0.125)
    meropenem:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    cephalothin:  S(10)
    kanamycin:  Res
    neomycin:  Res
    azithromycin:  SensRNG: (0.5-2)
    erythromycin:  S(60; disc, variable)
    clarithromycin:  S(0.125)
    roxithromycin:  SensRNG: (0.5-1)
    linezolid:  S(MIC50): 2, MIC90: 2, RNG: (2–4)
    moxifloxacin:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.125–0.25)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 1.25, RNG: (0.06–8)
    minocycline:  S(MIC50): 0.03, MIC90: 2, RNG: (0.03–2)
    tetracycline:  S(MIC50): 0.25, MIC90: 16, RNG: (0.25–16)
    tigecycline:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125–0.5)
    vancomycin:  Res
    metronidazole:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125–1)
    clindamycin:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.03–2)
    colistin:  S(10; disc, variable)
    polymyxin_B:  Res

    References

    SPECIFIC REFERENCES FOR BACTEROIDES PYOGENES
  • Benno1983 - Bacteroides pyogenes sp. nov., Bacteroides suis sp. nov., and Bacteroides helcogenes sp. nov., New Species from Abscesses and Feces of Pigs.
  • Wexler2007 - Bacteroides : the Good, the Bad, and the Nitty-Gritty.
  • Song2010Bergeys - Bacteroides. In Bergey's manual of systematic bacteriology: Vol. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes
  • Goldstein2018 - Comparative In Vitro Activity of Omadacycline against Dog and Cat Bite Wound Isolates.
  • Goldstein2017 - In Vitro Activity of Pexiganan and 10 Comparator Antimicrobials against 234 Isolates, Including 93 Pasteurella Species and 50 Anaerobic Bacterial Isolates Recovered from Animal Bite Wounds.
  • Goldstein2006c - Comparative in vitro susceptibilities of 396 unusual anaerobic strains to tigecycline and eight other antimicrobial agents.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BACTEROIDES PYOGENES
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • MacFarlane2004 - Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Urban2020 - Altered Fecal Microbiome Years after Traumatic Brain Injury
  • Woodmansey2004 - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects.
  • ...............................
    • GENERAL REFERENCES FOR BACTEROIDES PYOGENES
  • Song2010Bergeys - Bacteroides. In Bergey's manual of systematic bacteriology: Vol. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes
    • Added: April 08, 2021