Blautia coccoides

(aka Clostridium coccoides)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Blautia coccoides, (aka Clostridium coccoides), is a Gram-positive, spore-forming, strictly anaerobic, non-motile, oval-shaped bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 43-45%. Blautia coccoides is probably a common, although minor, coloniser of the gut. (Liu2008; Kaneuchi1976; Rainey2011gBergey)



  • This organism has been recovered from human faeces (Alkhalil2017) and caecum of mice. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • Homoacetogen.
    • GENERAL CHARACTERISTICS (Liu2008); (Kaneuchi1976); (Rainey2011gBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 💧
  • Bile tolerance:
  • Grows weakly in 20% bile
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 7.
  • 🌡
  • Temperature tolerance:
  • grows weakly at 15℃; grows at 25℃; grows at 45℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; fructose; galactose; glucose; mannose; rhamnose; ribose; sorbose; xylose; amygdalin; cellubiose; lactose; maltose; melezitose; melibiose; raffinose; sucrose; trehalose; dulcitol; inositol; sorbitol; α-methyl glucoside; methyl mannoside; salicin;
  • Active enzymes:
  • α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase;
    • SPECIAL FEATURES (Liu2008); (Kaneuchi1976); (Rainey2011gBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; succinate (major); H₂S (most strains; weak);
  • ✗
  • Metabolites not produced:
  • propionate; butyrate; lactate; ethanol; propanol; butanol; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Kaneuchi1976);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Aminoglycosides:
  • kanamycin;
  • Polypep/ketides:
  • rifampicin;
  • bacitracin;
  • Miscellaneous antibiotics:
  • colistin; polymyxin B;

  • Benno, Y., Suzuki, K., Suzuki, K., Narisawa, K., Bruce, W. R., & Mitsuoka, T. (1986). Comparison of the fecal microflora in rural Japanese and urban Canadians. Microbiology and Immunology, 30(6), 521–532.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Blautia Alt. name:  Clostridium coccoides Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Oval-shaped
    Health:  Unknown
    Source:  human faeces (Alkhalil2017) and caecum of mice
    DNA G+C(%):  43-45
    Opt. T:  37℃
    Low T(℃):  15(w)
    Lower T(℃):  25(+)
    High T(℃):  45(+)
    Opt. pH:  7
    Bile reaction(%):  20(w)
    		Aesculin:  + Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Milk:  curdle
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  + Ribose:  + Sorbose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  + Melibiose:  + Sucrose:  + Trehalose:  + Amygdalin:  + Dextrin:  neg Aesculin:  w Glycogen:  neg Inulin:  neg Starch:  w Dulcitol:  + Erythritol:  neg Glycerol:  w Inositol:  + Mannitol:  w Sorbitol:  + Me-α-D-Glc:  + Me-α-D-Mann:  + Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Lactate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  neg Butyrate:  neg Lactate:  neg Ethanol:  neg Propanol:  neg Butanol:  neg Succinate:  Major(+) H2S:  w(+) Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  S(15; disc)
    kanamycin:  R(1000; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    bacitracin:  R(3U)
    rifampicin:  S(15; disc)
    colistin:  R(10; disc)
    polymyxin_B:  R(10; disc)

    References

    SPECIFIC REFERENCES FOR BLAUTIA COCCOIDES
  • Liu2008 - Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces.
  • Benjamin2012 - Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota
  • Chen2019 - The alteration of gut microbiota in newly diagnosed type 2 diabetic patients
  • Hasegawa2015 - Intestinal Dysbiosis and Lowered Serum Lipopolysaccharide-Binding Protein in Parkinson's Disease
  • Jiang2017 - Alteration of the gut microbiota in Chinese population with chronic kidney disease
  • Joly2010 - Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome
  • Malinen2005 - Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR
  • Manichanh2006 - Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
  • Morita2015 - Gut Dysbiosis in Patients with Anorexia Nervosa
  • Mouzaki2013 - Intestinal microbiota in patients with nonalcoholic fatty liver disease
  • Murri2013 - Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study
  • Ohigashi2013 - Changes of the intestinal microbiota, short chain fatty acids, and fecal pH in patients with colorectal cancer
  • Sato2014 - Gut dysbiosis and detection of "live gut bacteria" in blood of Japanese patients with type 2 diabetes
  • Sokol2006 - Specificities of the fecal microbiota in inflammatory bowel disease
  • Sokol2009 - Low counts of Faecalibacterium prausnitzii in colitis microbiota
  • Yamashiro2017 - Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke
  • Kaneuchi1976 - Clostridium coccoides, a New Species from the Feces of Mice.
  • Rainey2011gBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XIVa
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BLAUTIA COCCOIDES
  • Benno1984 - The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants.
  • Benno1986 - Comparison of the fecal microflora in rural Japanese and urban Canadians.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR BLAUTIA COCCOIDES
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: April 08, 2021