Blautia hansenii

(aka Ruminococcus hansenii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Blautia hansenii, (aka Ruminococcus hansenii), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, oval-shaped bacterium. It has been detected in at least 22 gut microbiome compilation studies or metastudies. The DNA G+C content is 44-45%. Blautia hansenii is a common gut coloniser. (Holdeman1974; Liu2008; Ezaki1994; Ezaki2011aBergey)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Holdeman1974); (Liu2008); (Ezaki1994); (Ezaki2011aBergey);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 6.5% salt;
  • 🌡
  • Temperature tolerance:
  • grows weakly at 30℃; grows at 37℃; grows at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; lactose; maltose; raffinose;
  • ±
  • Strain-dependent acid from carbs:
  • aesculin;
  • ⥅
  • Substrates assimilated or utilised:
  • glucose; lactose; maltose; raffinose;
  • Active enzymes:
  • α-glucosidase;
    • SPECIAL FEATURES (Holdeman1974); (Liu2008); (Ezaki1994); (Ezaki2011aBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (minor); lactate (major); succinate (minor); H₂S;
  • ✗
  • Metabolites not produced:
  • H₂; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;

  • N/A

  • Blautia, within the family Lachnospiraceae, provide energy to their host from polysaccharides that other gut microorganisms cannot degrade. Blautia is a single microbial genus that is suggested to be important for nutrient assimilation. [PMID: 24936765] A rescent study has found that bacteria in the intestinal tract from the genus Blautia are associated with reduced mortality from GVHD. [PMID: 25977230]

    All ruminococci require fermentable carbohydrates for growth, and their substrate preferences appear to be based on the diet of their particular host. Most ruminococci that have been studied are those capable of degrading cellulose, much less is known about non-cellulolytic non-ruminant-associated species, and even less is known about the environmental distribution of ruminococci as a whole. [PMID: 28348838]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Blautia, within the family Lachnospiraceae, provide energy to their host from polysaccharides that other gut microorganisms cannot degrade. Blautia is a single microbial genus that is suggested to be important for nutrient assimilation. [PMID: 24936765]

    Ruminococcus species are defined as strictly anaerobic, Gram-positive, non-motile cocci that do not produce endospores and require fermentable carbohydrates for growth (Rainey, 2009b). They were initially described from the isolation of Ruminococcus flavefaciens from the bovine rumen (Sijpesteijn, 1948). Ruminococcus is currently considered a polyphyletic genus, with species members belonging to two separate families: the Ruminococcaceae and the Lachnospiraceae (Rainey & Janssen, 1995). Ruminococcus species are predominantly associated with herbivores and omnivores, relative to carnivores, and that significantly abundant Ruminococcus populations are absent in non-host-associated environments. [PMID: 28348838]

  • Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008). Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 58(Pt 8), 1896–1902.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Blautia Alt. name:  Ruminococcus hansenii Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Oval-shaped
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  44-45
    Lower T(℃):  30(w)
    Mid T(℃):  37(+)
    High T(℃):  45(+)
    NaCl >6%:  6.5(neg)
    		Aesculin:  vr Urea:  neg Starch:  neg Hippurate:  neg Milk:  curdle
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  neg Glucose:  + Mannose:  neg Ribose:  neg Sorbose:  neg Xylose:  neg Cellubiose:  neg Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  w Sucrose:  neg Trehalose:  neg Aesculin:  d(neg) Starch:  neg Adonitol:  neg Dulcitol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Glucose:  + Mannose:  neg Xylose:  neg Cellubiose:  neg Lactose:  + Maltose:  + Raffinose:  + Sucrose:  neg Gluconate:  neg Mannitol:  neg Lactate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  + β-Glucosidase:  vr β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  minor(+) Lactate:  Major(+) Succinate:  minor(+) H2S:  + H2:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR BLAUTIA HANSENII
  • Holdeman1974 - New Genus, Coprococcus, Twelve New Species, and Emended Descriptions of Four Previously Described Species of Bacteria from Human Feces.
  • Liu2008 - Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces.
  • Liu2021a - Blautia - a new functional genus with potential probiotic properties?.
  • Moore1995 - Intestinal floras of populations that have a high risk of colon cancer
  • Ezaki1994 - 16S Ribosomal DNA Sequences of Anaerobic Cocci and Proposal of Ruminococcus hansenii comb. nov. and Ruminococcus productus comb. nov.
  • Ezaki2011aBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Ruminococcaceae, Genus I. Ruminococcus
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BLAUTIA HANSENII
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Finegold1977 - Fecal microbial flora in Seventh Day Adventist populations and control subjects.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • Moore1974 - Human fecal flora: the normal flora of 20 Japanese-Hawaiians.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR BLAUTIA HANSENII
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • Alkhalil2017 - Bacterial involvements in ulcerative colitis: molecular and microbiological studies
    • Added: February 08, 2021