Blautia hydrogenotrophica

(aka Ruminococcus hydrogenotrophicus)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Blautia hydrogenotrophica, (aka Ruminococcus hydrogenotrophicus), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, coccobacillus bacterium. It has been detected in at least 21 gut microbiome compilation studies or metastudies. The DNA G+C content is 45.2%. Blautia hydrogenotrophica is a common gut coloniser. (Bernalier1996; Ezaki2011aBergey)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • QUIRKS
  • Homoacetogen.
    • GENERAL CHARACTERISTICS (Bernalier1996); (Ezaki2011aBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; urea;
  • pH
  • Acidity tolerance:
  • tolerates pH 7; Grows optimally at pH 6.6.
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 45℃; Grows optimally at 35-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; cellubiose;
  • ±
  • Strain-dependent acid from carbs:
  • mannose;
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; fructose; galactose; glucose; lactose; raffinose; salicin; trehalose; formate; pyruvate; H2 consumed; CO2 consumed;
  • Active enzymes:
  • fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; urease;
    • SPECIAL FEATURES (Bernalier1996); (Ezaki2011aBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (major); lactate (minor); isobutyrate (trace); ethanolminor; isovalerate (minor);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;

  • Bernalier, A., Willems, A., Leclerc, M., Rochet, V., & Collins, M. D. (1996). Ruminococcus hydrogenotrophicus sp. nov., a new H2/CO2-utilizing acetogenic bacterium isolated from human feces. Archives of Microbiology, 166(3), 176–183.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Blautia Alt. name:  Ruminococcus hydrogenotrophicus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Coccobacillus
    Health:   Positive
    Source:  human faeces
    DNA G+C(%):  45.2
    Opt. T:  35-37℃
    Lower T(℃):  30(+)
    High T(℃):  45(+)
    Opt. pH:  6.6
    pH 6.0-8.0:  7(+)
    		Aesculin:  + Urea:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Glucose:  + Mannose:  d Cellubiose:  + Sucrose:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  w Rhamnose:  neg Cellubiose:  + Lactose:  + Maltose:  w Melibiose:  neg Raffinose:  + Sucrose:  neg Trehalose:  + Amygdalin:  neg Inulin:  neg Mannitol:  neg Methanol:  neg Salicin:  + Sorbitol:  neg Starch:  neg Betaine:  neg Benzoate:  neg Formate:  + Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  + Ac-β-glcamnd:  neg α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  vr GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  Major(+) Lactate:  minor(+) Isobutyrate:  trace(+) Ethanol:  minor Isovalerate:  minor(+) Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR BLAUTIA HYDROGENOTROPHICA
  • Liu2021a - Blautia - a new functional genus with potential probiotic properties?.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Bernalier1996 - Ruminococcus hydrogenotrophicus sp. nov., a new H2 /CO2 -utilizing acetogenic bacterium isolated from human feces.
  • Ezaki2011aBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Ruminococcaceae, Genus I. Ruminococcus
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BLAUTIA HYDROGENOTROPHICA
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR BLAUTIA HYDROGENOTROPHICA
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021