Blautia luti

(aka Ruminococcus luti)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Blautia luti, (aka Ruminococcus luti), is a Gram-positive, non-spore-forming, strictly anaerobic, non-motile, oval-shaped bacterium. It has been detected in at least 7 gut microbiome compilation studies or metastudies. The DNA G+C content is 43.3%. Blautia luti is probably a common, although minor, coloniser of the gut. (Liu2008; Simmering2002; Ezaki2011aBergey)



  • This organism has been recovered from human faeces (CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Liu2008); (Simmering2002); (Ezaki2011aBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • H+
  • Acid from carbohydrates usually produced:
  • D-arabinose; L-arabinose; fructose; fucose; galactose; glucose; mannose; ribose; xylose; inulin; starch; cellubiose; lactose; maltose; melibiose; raffinose; sucrose; trehalose; sorbitol; N-Ac glucosamine;
  • ±
  • Strain-dependent acid from carbs:
  • amygdalin;
  • ⥅
  • Substrates assimilated or utilised:
  • arabinose; cellubiose; glucose; lactose; maltose; mannose; raffinose; sucrose; xylose;
  • Active enzymes:
  • alkaline phosphatase; arabinosidase; acid phosphatase; N-Ac α-glucosaminidase; N-Ac β-glucosaminidase; esterase C4; esterase lipase C8; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; α-mannosidase; xylosidase;
    • SPECIAL FEATURES (Liu2008); (Simmering2002); (Ezaki2011aBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (major); lactate (minor); ethanolminor; succinate; CO₂ (minor); H₂;
  • ✗
  • Metabolites not produced:
  • formate; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS
    Class Active Resistant
  • Quinolines:
  • ciprofloxacin;

  • All ruminococci require fermentable carbohydrates for growth, and their substrate preferences appear to be based on the diet of their particular host. Most ruminococci that have been studied are those capable of degrading cellulose, much less is known about non-cellulolytic non-ruminant-associated species, and even less is known about the environmental distribution of ruminococci as a whole. [PMID: 28348838]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Ruminococcus species are defined as strictly anaerobic, Gram-positive, non-motile cocci that do not produce endospores and require fermentable carbohydrates for growth (Rainey, 2009b). They were initially described from the isolation of Ruminococcus flavefaciens from the bovine rumen (Sijpesteijn, 1948). Ruminococcus is currently considered a polyphyletic genus, with species members belonging to two separate families: the Ruminococcaceae and the Lachnospiraceae (Rainey & Janssen, 1995). Ruminococcus species are predominantly associated with herbivores and omnivores, relative to carnivores, and that significantly abundant Ruminococcus populations are absent in non-host-associated environments. [PMID: 28348838]

  • Simmering, R, D Taras, A Schwiertz, GL Blay, B Gruhl, PA Lawson, MD Collins & M Blaut (2002). Ruminococcus luti sp. nov., isolated from a human faecal sample. Syst. Appl. Microbiol. 25: 189-193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Blautia Alt. name:  Ruminococcus luti Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Oval-shaped
    Health:  Unknown
    Source:  human faeces (CCUG)
    DNA G+C(%):  43.3
    		Aesculin:  + Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  + L-Arabinose:  + Fructose:  + Fucose:  + Galactose:  + Glucose:  + Mannose:  + Ribose:  + Sorbose:  neg Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melibiose:  + Sucrose:  + Trehalose:  + Amygdalin:  d Glycogen:  neg Inulin:  + Starch:  + Erythritol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  + NAc-α-GA:  + Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  + Glucose:  + Mannose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Raffinose:  + Sucrose:  + Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  neg α-Arab:  + Ac-α-glcamnd:  + Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  + Xylosidase:  + Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg ArgAA:  neg CystineAA:  neg GlyAA:  neg HisAA:  neg LeuAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  neg TyrAA:  neg ValAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lecithinase:  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  neg Acetate:  Major(+) Lactate:  minor(+) Ethanol:  minor Succinate:  + CO2:  minor(+) H2:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)

    References

    SPECIFIC REFERENCES FOR BLAUTIA LUTI
  • Liu2008 - Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces.
  • Liu2021a - Blautia - a new functional genus with potential probiotic properties?.
  • BenitezPaez2020 - Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Chua2018 - Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants
  • Coretti2018 - Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  • Miragoli2017 - Impact of cystic fibrosis disease on archaea and bacteria composition of gut microbiota
  • Luna2016 - Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder.
  • Simmering2002 - Ruminococcus luti sp. nov., Isolated from a Human Faecal Sample.
  • Ezaki2011aBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Ruminococcaceae, Genus I. Ruminococcus
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BLAUTIA LUTI
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR BLAUTIA LUTI
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
    • Added: April 08, 2021