Blautia wexlerae

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Blautia wexlerae is a Gram-positive, non-spore-forming, strictly anaerobic, coccobacillus bacterium. It has been detected in at least 13 gut microbiome compilation studies or metastudies. Blautia wexlerae is a common gut coloniser. (Liu2008a)



  • This organism has been recovered from human faeces. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • QUIRKS
  • In 100% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Liu2008a);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; urea;
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; glucose; xylose; aesculin;
  • ±
  • Strain-dependent acid from carbs:
  • cellubiose; lactose; maltose; raffinose; sucrose; mannitol;
  • ⥅
  • Substrates assimilated or utilised:
  • arabinose; glucose; mannose; ribose; xylose;
  • Active enzymes:
  • arabinosidase; acid phosphatase; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase;
  • ±
  • Strain-dependent active enzymes:
  • naphthol-ASBI-P;
    • SPECIAL FEATURES (Liu2008a);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (major); succinate;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Liu2008a);
    Class Active Resistant
  • Aminoglycosides:
  • kanamycin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • colistin;

  • Liu, C., Finegold, S. M., Song, Y., & Lawson, P. A. (2008). Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces. International Journal of Systematic and Evolutionary Microbiology, 58(Pt 8), 1896–1902.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Blautia Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  No spore Morphology:  Coccobacillus
    Health:  Unknown
    Source:  human faeces
    		Aesculin:  + Urea:  + Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Glucose:  + Mannose:  vr Xylose:  + Cellubiose:  d Lactose:  d Maltose:  d Sucrose:  d Aesculin:  + Mannitol:  d
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  + Fructose:  vr Glucose:  + Mannose:  + Rhamnose:  vr Ribose:  + Xylose:  + Cellubiose:  vr Lactose:  vr Maltose:  vr Melezitose:  vr Raffinose:  vr Sucrose:  vr Trehalose:  vr Amygdalin:  vr Glycogen:  neg Salicin:  vr Sorbitol:  vr
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  vr α-Arab:  + Ac-β-glcamnd:  neg α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  neg CystineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg ValAA:  neg AlkalineP:  neg AcidP:  + Esterase(C4):  vr EstLip(C8):  vr Lecithinase:  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  Major(+) Succinate:  + Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    kanamycin:  S(1000; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(5; disc)
    colistin:  R(10; disc)

    References

    SPECIFIC REFERENCES FOR BLAUTIA WEXLERAE
  • Liu2021a - Blautia - a new functional genus with potential probiotic properties?.
  • Liu2008a - Reclassification of Clostridium coccoides, Ruminococcus hansenii, Ruminococcus hydrogenotrophicus, Ruminococcus luti, Ruminococcus productus and Ruminococcus schinkii as Blautia coccoides gen. nov., comb. nov., Blautia hansenii comb. nov., Blautia hydrogenotrophica comb. nov., Blautia luti comb. nov., Blautia producta comb. nov., Blautia schinkii comb. nov. and description of Blautia wexlerae sp. nov., isolated from human faeces 2
  • BenitezPaez2020 - Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Coretti2018 - Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  • Luo2018 - Gut Microbiota in Human Systemic Lupus Erythematosus and a Mouse Model of Lupus
  • Wang2019d - Gut Microbiota Dysbiosis Is Associated with Altered Bile Acid Metabolism in Infantile Cholestasis
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BLAUTIA WEXLERAE
  • Almeida2019 - A new genomic blueprint of the human gut microbiota.
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Dubourg2013 - The gut microbiota of a patient with resistant tuberculosis is more comprehensively studied by culturomics than by metagenomics.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • ...............................
    • GENERAL REFERENCES FOR BLAUTIA WEXLERAE
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021