Bordetella bronchiseptica

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Bordetella bronchiseptica is a Gram-negative, non-spore-forming, strictly aerobic, motile, coccobacillus bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 67-69%. Bordetella bronchiseptica is unlikely to be a gut coloniser. (Sanden2005Bergey)



  • This organism has been recovered from the respiratory systems of animals and humans. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a known human pathogen. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Few isolates from humans; likely a gut non-coloniser
    • GENERAL CHARACTERISTICS (Sanden2005Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • urea;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 52℃; Grows optimally at 35-37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • alanine; aspartate; glutamate; glycine; proline; serine; adipate; citrate; malonate; phenylacetate; valerate; glutamine;
  • ±
  • Strain-dependent substrate utilisation:
  • caprate; L-malate;
  • Active enzymes:
  • Ala arylamidase; acid phosphatase; Arg arylamidase; Asp arylamidase; catalase; esterase C4; Gly arylamidase; Leu arylamidase; Leu-Gly arylamidase; oxidase; Ser arylamidase; Tyr arylamidase; urease;
  • ±
  • Strain-dependent active enzymes:
  • alkaline phosphatase; esterase lipase C8;
    • SPECIAL FEATURES (Sanden2005Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • ammonia; COâ‚‚;
  • ±
  • Nitrate:
  • strain dependent
    • RESPONSE TO ANTIBIOTICS (Goldstein2003a); (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • amoxicillin-clavulanic acid;
  • Cephalosporins:
  • cefuroxime;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • chlortetracycline; doxycycline; minocycline; tetracycline;
  • Quinolines:
  • levofloxacin; moxifloxacin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Betaproteobacteria Order:  Burkholderiales Family:  Alcaligenaceae Genus:  Bordetella Gram stain:  neg O2 Relation.:  strictly aerobic Spore:  No spore Motility:  Swimming Morphology:  Coccobacillus
    Health:  Unknown
    Source:  the respiratory systems of animals and humans
    DNA G+C(%):  67-69
    Opt. T:  35-37℃
    Lower T(℃):  25(+)
    High T(℃):  52(+)
    		Urea:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Glucose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Aesculin:  neg Gluconate:  neg Mannitol:  neg Ala:  + Asp:  + Glu:  + Gly:  + Pro:  + Ser:  + Adipate:  + Caprate:  d Citrate:  + 2-Ketogluconate:  neg 5-Ketogluconate:  neg L-Malate:  d Malonate:  + Phenylacetate:  + Valerate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  + Chymotrypsin:  neg LysDC:  neg Trypsin:  neg AlanineAA:  + ArgAA:  + AspAA:  + CystineAA:  neg GluGluAA:  neg GlyAA:  + LeuAA:  + LeuGlyAA:  + ProAA:  neg PheAA:  neg PyrogluAA:  neg SerAA:  + TyrAA:  + ValAA:  neg AlkalineP:  d AcidP:  + Esterase(C4):  + EstLip(C8):  d Lipase(C14):  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  R(MIC50): >16, MIC90: >16, RNG: (1–>16)
    penicillin_G:  S(MIC50): 0.06, MIC90: 0.25, RNG: (≤0.015–4)
    cefuroxime:  R(MIC50): >32, MIC90: >32, RNG: (0.5–>32)
    azithromycin:  S(MIC50): 0.25, MIC90: 1, RNG: (≤0.015–1)
    erythromycin:  S(MIC50): 0.06, MIC90: 8, RNG: (≤0.015–8)
    gatifloxacin:  Var(MIC50): 1, MIC90: 8, RNG: (0.03–16)
    levofloxacin:  S(MIC50): ≤0.015, MIC90: 0.125, RNG: (≤0.015–0.25)
    moxifloxacin:  S(MIC50): ≤0.015, MIC90: 0.06, RNG: (≤0.015–.125)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 0.5, RNG: (≤0.015–0.5)
    chlortetracycline:  SensRNG: (≤0.5-1)
    minocycline:  S(MIC50): 0.06, MIC90: 0.125, RNG: (≤0.015–0.25)
    tetracycline:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.03–0.25)
    vancomycin:  S(MIC50): 0.8, MIC90: 0.8, RNG: (≤0.015–>8)
    clindamycin:  R(MIC50): >32, MIC90: >32, RNG: (4–>32)

    References

    SPECIFIC REFERENCES FOR BORDETELLA BRONCHISEPTICA
  • vanderZee1996 - The differentiation of Bordetella parapertussis and Bordetella bronchiseptica from humans and animals as determined by DNA polymorphism mediated by two different insertion sequence elements suggests their phylogenetic relationship.
  • Register1997 - MR. Use of ribotyping to distinguish Bordetella bronchiseptica isolates.
  • Khattak1993 - Genetic relatedness of Bordetella species as determined by macrorestriction digests resolved by pulsed-field gel electrophoresis.
  • Sanden2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Alcaligenaceae, Genus III. Bordetella
  • Goldstein2003a - In vitro activities of ABT-492, a new fluoroquinolone, against 155 aerobic and 171 anaerobic pathogens isolated from antral sinus puncture specimens from patients with sinusitis.
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BORDETELLA BRONCHISEPTICA
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
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    • Added: January 14, 2022