Brevibacterium otitidis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Brevibacterium otitidis is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, diphtheroidal bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. Brevibacterium otitidis is unlikely to be a gut coloniser. (Wauters2001; Talento2013)



  • This organism has been recovered from clinical sources (ear infection, cyst). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). Is a rare opportunistic pathogen. Likely to be transient and not a long-term gut commensal.
    • GENERAL CHARACTERISTICS (Wauters2001);
    Character Response
  • Substrates hydrolysed or digested:
  • casein; gelatin;
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 20℃; grows at 37℃;
  • Active enzymes:
  • catalase; pyrrolidine arylamidase;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • Pigments:
  • yellow
    • RESPONSE TO ANTIBIOTICS (Talento2013);
    Class Active Resistant
  • Penicillins:
  • penicillin;
  • Cephalosporins:
  • cefotaxime;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Polypep/ketides:
  • rifampicin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Micrococcales Family:  Brevibacteriaceae Genus:  Brevibacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Diphtheroidal Pigment:  yellow
    Health:  Unknown
    Source:  clinical sources (ear infection, cyst)
    Lower T(℃):  20(neg)
    Mid T(℃):  37(+)
    		Gelatin:  + Casein:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Gluconate:  neg Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + α-Glucosidase:  neg PyrrolidAA:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Pigment:  yellow
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  R(1)
    cefotaxime:  S(1)
    erythromycin:  S(0.125)
    linezolid:  S(0.25)
    ciprofloxacin:  S(0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(0.25)
    vancomycin:  S(0.125)
    rifampicin:  S(0.002)
    clindamycin:  R(8)
    daptomycin:  S(0.25)

    References

    SPECIFIC REFERENCES FOR BREVIBACTERIUM OTITIDIS
  • Wauters2001 - Brevibacterium paucivorans sp. nov., from human clinical specimens.
  • Talento2013 - Brevibacterium otitidis: an elusive cause of neurosurgical infection.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BREVIBACTERIUM OTITIDIS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • ...............................
    • Added: January 14, 2022