Brevibacterium ravenspurgense

(aka Brevibacterium massiliense)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Brevibacterium ravenspurgense, (aka Brevibacterium massiliense), is a Gram-positive, non-spore-forming, aerobic, non-motile, rod-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. Brevibacterium ravenspurgense is probably a rare gut coloniser. (Bernard2016; Roux2009)



  • This organism has been recovered from clinical sources (blood, wound, vagina - CCUG) and human faeces. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Bernard2016); (Roux2009);
    Character Response
  • 🧂
  • Salt tolerance:
  • tolerates 0% salt; tolerates 10% salt;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 45℃; Grows optimally at 30-37℃.
  • ⥅
  • Substrates assimilated or utilised:
  • alanine; D-alanine; glutamate; serine; acetate; 3-hydroxybutyrate; propionate; pyruvate; 2,3-butanediol; glutamine; L-asparagine; alaninamide; α-ketovalerate; 2-hydroxybutyrate; methyl succinate; methyl pyruvate; L-lactate;
  • Active enzymes:
  • Ala arylamidase; Arg arylamidase; catalase; esterase C4; Gly arylamidase; Leu arylamidase; Leu-Gly arylamidase; Phe arylamidase; Pro arylamidase; Ser arylamidase; Tyr arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • naphthol-ASBI-P;
    • SPECIAL FEATURES (Bernard2016); (Roux2009);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Bernard2016);
    Class Active Resistant
  • Penicillins:
  • meropenem; penicillin;
  • Cephalosporins:
  • cefepime; cefotaxime;
  • Macrolides:
  • quinupristin-dalfopristin;
  • Tetracyclines:
  • tetracycline;
  • Polypep/ketides:
  • rifampicin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;

  • Pfleiderer, A., Lagier, J.-C., Armougom, F., Robert, C., Vialettes, B., & Raoult, D. (2013). Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample. European Journal of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology, 32(11), 1471–1481.

    Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Micrococcales Family:  Brevibacteriaceae Genus:  Brevibacterium Alt. name:  Brevibacterium massiliense Gram stain:  + O2 Relation.:  aerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  clinical sources (blood, wound, vagina - CCUG) and human faeces
    Opt. T:  30-37℃
    Lower T(℃):  25(+)
    High T(℃):  45(+)
    NaCl 0.5-2%:  0(+)
    NaCl >6%:  10(+)
    		Aesculin:  neg Urea:  neg Gelatin:  neg Tween:  40(+) 80(+)
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  neg Fructose:  neg Fucose:  neg D-Fucose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  neg Sorbose:  neg D-Tagatose:  neg Xylose:  neg L-Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Sucrose:  neg Trehalose:  neg Turanose:  neg Amygdalin:  neg Glycogen:  neg Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  neg Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  neg Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg L-Arabinose:  neg Fructose:  neg Fucose:  neg Galactose:  neg Glucose:  neg Mannose:  neg Rhamnose:  neg Ribose:  vr D-Tagatose:  neg Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  neg Maltotriose:  neg Melezitose:  neg Melibiose:  neg Raffinose:  neg Sucrose:  neg D-Turanose:  neg Trehalose:  neg N_Acetyl_glucosamine:  neg Amygdalin:  neg Arbutin:  neg Dextrin:  neg Gluconate:  neg Glycogen:  neg Inositol:  neg Mannitol:  neg Me-α-D-Glc:  neg Salicin:  neg Sorbitol:  neg Xylitol:  neg Ala:  + D-Ala:  + Glu:  + Ser:  + Acetate:  + 3-Hydroxybutyrate:  + 4-Hydroxybenzoate:  neg 2-Ketogluconate:  neg Malate:  neg L-Malate:  neg Propionate:  + Pyruvate:  + Succinate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Urease:  neg α-Arab:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg GluDC:  neg Trypsin:  neg AlanineAA:  + ArgAA:  + CystineAA:  neg GluGluAA:  neg GlyAA:  + HisAA:  w LeuAA:  + LeuGlyAA:  + ProAA:  + PyrrolidAA:  neg PheAA:  + PyrogluAA:  neg SerAA:  + TyrAA:  + ValAA:  neg AlkalineP:  neg AcidP:  neg Esterase(C4):  + EstLip(C8):  w Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  Sens
    meropenem:  Sens
    cefepime:  Sens
    cefotaxime:  Sens
    gentamicin:  Var
    erythromycin:  I
    quin-dalf:  Sens
    linezolid:  Sens
    ciprofloxacin:  I
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    vancomycin:  Sens
    rifampicin:  Sens
    SXT:  Var
    clindamycin:  I
    daptomycin:  Sens

    References

    SPECIFIC REFERENCES FOR BREVIBACTERIUM RAVENSPURGENSE
  • Bernard2016 - Brevibacterium massiliense (Roux and Raoult 2009) is a later heterotypic synonym of Brevibacterium ravenspurgense (Mages, Frodl, Bernard and Funke 2009), using whole-genome sequence analysis as a comparative tool.
  • Roux2009 - Brevibacterium massiliense sp. nov., isolated from a human ankle discharge.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BREVIBACTERIUM RAVENSPURGENSE
  • Dubourg2013 - The gut microbiota of a patient with resistant tuberculosis is more comprehensively studied by culturomics than by metagenomics.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021