Butyricicoccus pullicaecorum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Butyricicoccus pullicaecorum is a Gram-positive, anaerobic, non-motile, coccus bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 54.5%. Butyricicoccus pullicaecorum is probably a common, although minor, coloniser of the gut. (Eeckhaut2008)



  • This organism has been recovered from human faeces, and caeca of a chicken. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal. Robust growth can have positive consequences for gut health.
    • QUIRKS
  • In 65% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Eeckhaut2008);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; xylose; cellubiose; maltose; sucrose; trehalose; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • acetate;
  • ±
  • Strain-dependent substrate utilisation:
  • propionate;
  • Active enzymes:
  • esterase C4; β-galactosidase;
    • SPECIAL FEATURES (Eeckhaut2008);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); butyrate (major); CO₂; H₂;
    • RESPONSE TO ANTIBIOTICS (Steppe2014);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; ampicillin-sulbactam; imipenem; meropenem; mezlocillin; piperacillin-tazobactam;
  • Cephalosporins:
  • cefotetan; cefoxitin;
  • Tetracyclines:
  • tetracycline;
  • Aminoglycosides:
  • gentamicin; kanamycin; streptomycin;
  • Heterocycles:
  • chloramphenicol; metronidazole;
  • trimethoprim;
  • Vancomycins:
  • vancomycin;

  • Eeckhaut, V., Machiels, K., Perrier, C., Romero, C., Maes, S., Flahou, B., Steppe, M., Haesebrouck, F., Sas, B., Ducatelle, R., Vermeire, S., & Van Immerseel, F. (2013). Butyricicoccus pullicaecorum in inflammatory bowel disease. Gut, 62(12), 1745–1752.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Butyricicoccus Gram stain:  + O2 Relation.:  anaerobic Motility:  Sessile Morphology:  Coccus
    Health:   Positive
    Source:  human faeces, and caeca of a chicken
    DNA G+C(%):  54.5
    		Aesculin:  + Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  + Cellubiose:  + Lactose:  neg Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  + Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Acetate:  + Propionate:  d
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Urease:  neg β-Galactosidase:  + LeuAA:  neg AlkalineP:  neg Esterase(C4):  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(≤0.25/0.5)
    ampicillin:  S(0.25)
    amp-sulb:  S(≤0.25/0.5)
    mezlocillin:  S(≤4)
    piper-taz:  S(2/4)
    imipenem:  S(1)
    meropenem:  S(≤0.5)
    cefotetan:  S(≤4)
    cefoxitin:  S(8)
    gentamicin:  R(>128)
    kanamycin:  R(>128)
    streptomycin:  R(>128)
    erythromycin:  Var(MIC50): 1->128), MIC90: Var(1->128
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(1)
    vancomycin:  S(0.25)
    chloramphenicol:  S(1)
    metronidazole:  S(≤0.5)
    trimethoprim:  R(>128)
    clindamycin:  Var(MIC50): ≤0.06-128), MIC90: Var(≤0.06-128

    References

    SPECIFIC REFERENCES FOR BUTYRICICOCCUS PULLICAECORUM
  • Chang2020 - A gut butyrate-producing bacterium Butyricicoccus pullicaecorum regulates short-chain fatty acid transporter and receptor to reduce the progression of 1,2-dimethylhydrazine-associated colorectal cancer.
  • Eeckhaut2008 - Butyricicoccus pullicaecorum gen. nov., sp. nov., an anaerobic, butyrate-producing bacterium isolated from the caecal content of a broiler chicken.
  • Eeckhaut2016 - The Probiotic Butyricicoccus pullicaecorum Reduces Feed Conversion and Protects from Potentially Harmful Intestinal Microorganisms and Necrotic Enteritis in Broilers.
  • Steppe2014 - Safety assessment of the butyrate-producing Butyricicoccus pullicaecorum strain 25-3T, a potential probiotic for patients with inflammatory bowel disease, based on oral toxicity tests and whole genome sequencing.
  • Bojovic2020 - Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders
  • Bajer2017 - Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Gryp2020 - Isolation and Quantification of Uremic Toxin Precursor-Generating Gut Bacteria in Chronic Kidney Disease Patients
  • Huang2019 - Analysis of microbiota in elderly patients with Acute Cerebral Infarction
  • Opstelten2016 - Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease
  • Laue2020 - Prospective associations of the infant gut microbiome and microbial function with social behaviors related to autism at age 3 years
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR BUTYRICICOCCUS PULLICAECORUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • GENERAL REFERENCES FOR BUTYRICICOCCUS PULLICAECORUM
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021