Campylobacter coli

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Campylobacter coli is a Gram-negative, non-spore-forming, microaerophilic, motile, corkscrew-shaped bacterium. It has been detected in at least 7 gut microbiome compilation studies or metastudies. The DNA G+C content is 31–35%. Campylobacter coli is likely to be transient and not a long-term gut coloniser. (Vandamme1991; VanDamme2005Bergey)



  • This organism has been recovered from human faeces and clinical sources (blood - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). Is a known human pathogen. A possible gut commensal. Robust growth can have negative consequences for gut health.
    • QUIRKS
  • Pathogenic; unlikely to be a coloniser in a healthy microbiome.
    • GENERAL CHARACTERISTICS (Vandamme1991); (VanDamme2005Bergey);
    Character Response
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 2.0% salt;
  • 💧
  • Bile tolerance:
  • Strain-variable at 2%
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 25℃; grows at 42℃;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; catalase; esterase C4; esterase lipase C8; Leu arylamidase; oxidase;
  • ±
  • Strain-dependent active enzymes:
  • γ-Glu transferase;
    • SPECIAL FEATURES (VanDamme2005Bergey);
    Character Response
  • ✓
  • Metabolites produced:
  • H₂S (variable);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • VP test:
  • not active
  • ±
  • Haemolysis:
  • d(neg)
  • ✓
  • Nitrate:
  • reduced
  • ✗
  • Nitrite:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (VanDamme2005Bergey);
    Class Active Resistant
  • Penicillins:
  • ampicillin;
  • amoxicillin; carbenicillin;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • spiramycin;
  • erythromycin;
  • Tetracyclines:
  • tetracycline; tigecycline;
  • Quinolines:
  • nalidixic-acid; norfloxacin;
  • Aminoglycosides:
  • gentamicin; neomycin; spectinomycin;
  • streptomycin;
  • Heterocycles:
  • chloramphenicol;
  • metronidazole;
  • Miscellaneous antibiotics:
  • colistin;
  • clindamycin;
  • NOTES

    Media containing 1% glycine supports growth.

  • Bacterium Selenite reduction H2S/TSI Nitrate reduction Oxidase Catalase Indoxyl acetate hydrolysis
    Campylobacter coli + d + + + +
    Campylobacter upsaliensis + neg + + neg +
    Campylobacter rectus + neg + + d +
    Campylobacter showae + d + d + neg
    Campylobacter concisus d neg d d neg neg
    Campylobacter curvus neg d + + neg d
    Campylobacter gracilis neg neg d neg d d
    Campylobacter hominis neg neg neg + neg neg

  • Campylobacter coli strain YH502 isolated from retail chicken in the United States. Multiple virulence factors including a plasmid-borne type VI secretion system and antimicrobial resistance genes (beta-lactams, fluoroquinolones, and aminoglycoside) were found. [PMID: 28217442]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Penner, J. L., & Hennessy, J. N. (1980). Passive hemagglutination technique for serotyping Campylobacter fetus subsp. jejuni on the basis of soluble heat-stable antigens. Journal of Clinical Microbiology, 12(6), 732–737.

  • Penner, J. L., & Hennessy, J. N. (1980). Passive hemagglutination technique for serotyping Campylobacter fetus subsp. jejuni on the basis of soluble heat-stable antigens. Journal of Clinical Microbiology, 12(6), 732–737.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Epsilonproteobacteria Order:  Campylobacterales Family:  Campylobacteraceae Genus:  Campylobacter Gram stain:  neg O2 Relation.:  microaerophilic Spore:  No spore Motility:  Swimming Morphology:  Corkscrew
    Health:   Negative
    Source:  human faeces and clinical sources (blood - CCUG)
    DNA G+C(%):  31–35
    Lower T(℃):  25(neg)
    High T(℃):  42(+)
    NaCl 0.5-2%:  2.0(neg)
    Bile reaction(%):  2(d)
    		Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Tyrosine:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Mannose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Hippurate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg γ-Glu transf.:  d GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  + LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lecithinase:  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  vr Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Res
    ampicillin:  S(16)
    carbenicil:  R(32,vr)
    cephalothin:  R(MIC50): 30), MIC90: R(30, R(32)
    gentamicin:  S(1)
    kanamycin:  Var
    neomycin:  S(4)
    spectinomycin:  S(16)
    streptomycin:  R(vr)
    erythromycin:  R(2,vr)
    clarithromycin:  Var(MIC50): 0.03-128), MIC90: Var(0.03-128
    spiramycin:  S(128)
    nalidixic-acid:  S(32)
    norfloxacin:  S(10)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Var(MIC50): 0.06-128), MIC90: Var(0.06-128
    tetracycline:  S(2)
    tigecycline:  SensRNG: (0.03-0.06)
    chloramphenicol:  S(8)
    metronidazole:  R(4, vr)
    SXT:  Var
    clindamycin:  R(2)
    colistin:  S(16)

    References

    SPECIFIC REFERENCES FOR CAMPYLOBACTER COLI
  • Vandamme1991 - Revision of Campylobacter, Helicobacter, and Wolinella Taxonomy: Emendation of Generic Descriptions and Proposal of Arcobacter gen. nov.
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CAMPYLOBACTER COLI
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR CAMPYLOBACTER COLI
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • VanDamme2005aBergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus II. Arcobacter
    • Added: February 08, 2021