Campylobacter hominis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Campylobacter hominis is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 10 gut microbiome compilation studies or metastudies. The DNA G+C content is 32–33%. Campylobacter hominis is probably a common, although minor, coloniser of the gut. (Lawson2001; VanDamme2005Bergey; Liu2018a)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Lawson2001); (VanDamme2005Bergey);
    Character Response
  • 🧂
  • Salt tolerance:
  • strain-variable at 2.0(d)%; doesn't tolerate 4% salt;
  • 💧
  • Bile tolerance:
  • Strain-variable at 2%
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 25℃; strain-variable at 42(d); Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose;
  • ⥅
  • Substrates assimilated or utilised:
  • glycine;
  • Active enzymes:
  • oxidase;
    • SPECIAL FEATURES (Lawson2001); (VanDamme2005Bergey);
    Character Response
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Lawson2001); (VanDamme2005Bergey);
    Class Active Resistant
  • Penicillins:
  • carbenicillin;
  • Cephalosporins:
  • cephalothin;
  • Quinolines:
  • nalidixic-acid;
  • NOTES

    Media containing 1% glycine supports growth.

  • Bacterium Selenite reduction H2S/TSI Nitrate reduction Oxidase Catalase Indoxyl acetate hydrolysis
    Campylobacter coli + d + + + +
    Campylobacter upsaliensis + neg + + neg +
    Campylobacter rectus + neg + + d +
    Campylobacter showae + d + d + neg
    Campylobacter concisus d neg d d neg neg
    Campylobacter curvus neg d + + neg d
    Campylobacter gracilis neg neg d neg d d
    Campylobacter hominis neg neg neg + neg neg

  • All isolates exhibited the typical Campylobacter characteristics of being non-fermentative, oxidase-positive, catalase-negative and Gram-negative. Unusually, however, they were straight rods lacking flagella. [PMID: 11321111]

  • GutFeeling KnowledgeBase COMMENTS [Website]

    Campylobacter hominis is the only known campylobacter species that is not pathogenic to humans. Strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A is the type strain that was isolated in 2001 from the feces of a healthy human. The genome of Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A) is made up of one chromosome and one plasmid. [UP000002407]

  • Lawson, A. J., On, S. L., Logan, J. M., & Stanley, J. (2001). Campylobacter hominis sp. nov., from the human gastrointestinal tract. International Journal of Systematic and Evolutionary Microbiology, 51(Pt 2), 651–660.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Epsilonproteobacteria Order:  Campylobacterales Family:  Campylobacteraceae Genus:  Campylobacter Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces
    DNA G+C(%):  32–33
    Opt. T:  37℃
    Lower T(℃):  25(neg)
    High T(℃):  42(d)
    NaCl 0.5-2%:  2.0(d)
    NaCl 3-5%:  4(neg)
    Bile reaction(%):  2(d)
    		Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Tyrosine:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Gly:  + Hippurate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  neg Urease:  neg γ-Glu transf.:  neg PyrrolidAA:  neg AlkalineP:  neg Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    carbenicil:  S(32)
    cephalothin:  S(32)
    nalidixic-acid:  R(32,vr)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    metronidazole:  Var(MIC50): 4), MIC90: Var(4

    References

    SPECIFIC REFERENCES FOR CAMPYLOBACTER HOMINIS
  • Lawson2001 - Campylobacter hominis sp. nov., from the human gastrointestinal tract.
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • Liu2018a - The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CAMPYLOBACTER HOMINIS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR CAMPYLOBACTER HOMINIS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • VanDamme2005aBergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus II. Arcobacter
    • Added: February 08, 2021