Campylobacter jejuni subsp. jejuni

(aka Campylobacter jejuni)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Campylobacter jejuni subsp. jejuni, (aka Campylobacter jejuni), is a Gram-negative, non-spore-forming, microaerophilic, motile, vibrio bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 30-33%. Campylobacter jejuni subsp. jejuni is likely to be transient and not a long-term gut coloniser. (Vandamme1991; VanDamme2005Bergey; Jones1931; Steele1988)



  • This organism has been recovered from human faeces and clinical sources (blood - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). Is a known human pathogen. A possible gut commensal.
    • QUIRKS
  • Pathogenic; unlikely to be a coloniser in a healthy microbiome.
    • GENERAL CHARACTERISTICS (Vandamme1991); (VanDamme2005Bergey); (Jones1931); (Steele1988);
    Character Response
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 2% salt;
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 25℃; grows at 42℃;
  • ⥅
  • Substrates assimilated or utilised:
  • glycine;
  • Active enzymes:
  • alkaline phosphatase; catalase; oxidase;
    • SPECIAL FEATURES (VanDamme2005Bergey); (Steele1988);
    Character Response
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✗
  • VP test:
  • not active
  • ✓
  • Nitrate:
  • reduced
  • ✗
  • Nitrite:
  • not reduced
  • ✓
  • NO3➔NO2:
  • reduced
    • RESPONSE TO ANTIBIOTICS (VanDamme2005Bergey); (Kamoda2006); (Steele1988);
    Class Active Resistant
  • Penicillins:
  • ampicillin; imipenem;
  • amoxicillin;
  • Cephalosporins:
  • cefoperazone; cephalothin;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin; spiramycin;
  • Tetracyclines:
  • tetracycline; tigecycline;
  • Quinolines:
  • ciprofloxacin; nalidixic-acid; norfloxacin;
  • Aminoglycosides:
  • amikacin; apramycin; gentamicin;
  • Heterocycles:
  • chloramphenicol; trimethoprim-sulfamethoxazole;
  • metronidazole;
  • Miscellaneous antibiotics:
  • clindamycin; colistin;
  • GutFeeling KnowledgeBase COMMENTS [Website]

    Campylobacter jejuni ICDCCJ07001 (HS:41, ST2993) was isolated from a Guillain-Barré syndrome (GBS) patient during a 36-case GBS outbreak triggered by C. jejuni infections in north China in 2007.[PMID: 21124772]

  • Paisley, J. W., Mirrett, S., Lauer, B. A., Roe, M., & Reller, L. B. (1982). Dark-field microscopy of human feces for presumptive diagnosis of Campylobacter fetus subsp. jejuni enteritis. Journal of Clinical Microbiology, 15(1), 61–63.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Epsilonproteobacteria Order:  Campylobacterales Family:  Campylobacteraceae Genus:  Campylobacter Alt. name:  Campylobacter jejuni Gram stain:  neg O2 Relation.:  microaerophilic Spore:  No spore Motility:  Swimming Morphology:  Vibrio
    Health:  Unknown
    Source:  human faeces and clinical sources (blood - CCUG)
    DNA G+C(%):  30-33
    Lower T(℃):  25(neg)
    High T(℃):  42(+)
    NaCl 0.5-2%:  2(neg)
    		Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Tyrosine:  neg Hippurate:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Gly:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  neg GluDC:  neg AlkalineP:  + Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  R, Var(MIC50): 0.5-2), MIC90: R, Var(0.5-2
    ampicillin:  S(16)
    carbenicil:  Var(MIC50): 32), MIC90: Var(32
    imipenem:  S(10)
    cefoperazone:  Res
    cephalothin:  R(32)
    amikacin:  Sens
    apramycin:  S(2)
    gentamicin:  S(1)
    spectinomycin:  Var(MIC50): 64), MIC90: Var(64
    streptomycin:  Var
    azithromycin:  S(15,vr)
    erythromycin:  S(4)
    clarithromycin:  SensRNG: (0.25-1)
    spiramycin:  S(8)
    ciprofloxacin:  S(5,vr)
    nalidixic-acid:  S(MIC50): 30), MIC90: S(30, S(32)
    norfloxacin:  S(10)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Var(MIC50): 0.06-128), MIC90: Var(0.06-128
    tetracycline:  S(MIC50): 1), MIC90: S(1, Var(30)
    tigecycline:  SensRNG: (0.03-0.06)
    chloramphenicol:  S(8)
    metronidazole:  R(32->64)
    SXT:  S(vr)
    clindamycin:  S(2)
    colistin:  S(16)

    References

    SPECIFIC REFERENCES FOR CAMPYLOBACTER JEJUNI SUBSP. JEJUNI
  • Vandamme1991 - Revision of Campylobacter, Helicobacter, and Wolinella Taxonomy: Emendation of Generic Descriptions and Proposal of Arcobacter gen. nov.
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • Jones1931 - Vibrios (Vibrio Jejuni, n. sp.) Associated with Intestinal Disorders of Cows and Calves.
  • Kamoda2006 - In Vitro Activity of a Novel Antimicrobial Agent, TG44, for Treatment of Helicobacter pylori Infection.
  • Steele1988 - Notes: Campylobacter jejuni subsp. doylei subsp. nov., a Subspecies of Nitrate-Negative Campylobacters Isolated from Human Clinical Specimens.
  • Newburg2015 - Neonatal Gut Microbiota and Human Milk Glycans Cooperate to Attenuate Infection and Inflammation
  • Wang2019a - Alterations in Gut Glutamate Metabolism Associated with Changes in Gut Microbiota Composition in Children with Autism Spectrum Disorder
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CAMPYLOBACTER JEJUNI SUBSP. JEJUNI
  • Almeida2019 - A new genomic blueprint of the human gut microbiota.
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • King2019 - Baseline human gut microbiota profile in healthy people and standard reporting template.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR CAMPYLOBACTER JEJUNI SUBSP. JEJUNI
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • VanDamme2005aBergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus II. Arcobacter
    • Added: July 12, 2021