Campylobacter upsaliensis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Campylobacter upsaliensis is a Gram-negative, non-spore-forming, microaerophilic, motile, rod-shaped - curved bacterium. It has been detected in at least 5 gut microbiome compilation studies or metastudies. The DNA G+C content is 32-36%. Campylobacter upsaliensis is probably a rare gut coloniser. (Sandstedt1991; Vandamme1991; VanDamme2005Bergey)



  • This organism has been recovered from human faeces, clinical sources (blood - CCUG) and animals. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: zoonotic pathogen). Is a rare opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Sandstedt1991); (Vandamme1991); (VanDamme2005Bergey);
    Character Response
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 1.5% salt;
  • 💧
  • Bile tolerance:
  • Resistant to 2% bile
  • 🌡
  • Temperature tolerance:
  • doesn't grow at 25℃; grows at 31℃; grows at 42℃;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; oxidase;
    • SPECIAL FEATURES (Sandstedt1991); (VanDamme2005Bergey);
    Character Response
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✗
  • VP test:
  • not active
  • ✓
  • Nitrate:
  • reduced
  • ✗
  • Nitrite:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Sandstedt1991); (VanDamme2005Bergey);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; carbenicillin; meropenem; piperacillin-tazobactam; ticarcillin-clavulanic acid;
  • Cephalosporins:
  • cefoperazone; ceftizoxime; cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • minocycline; tetracycline;
  • Quinolines:
  • nalidixic-acid;
  • Aminoglycosides:
  • gentamicin; kanamycin; streptomycin;
  • Polypep/ketides:
  • bacitracin;
  • Heterocycles:
  • chloramphenicol; trimethoprim;
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; colistin; polymyxin B;
  • NOTES

    Media containing 1% glycine supports growth.

  • Bacterium Selenite reduction H2S/TSI Nitrate reduction Oxidase Catalase Indoxyl acetate hydrolysis
    Campylobacter coli + d + + + +
    Campylobacter upsaliensis + neg + + neg +
    Campylobacter rectus + neg + + d +
    Campylobacter showae + d + d + neg
    Campylobacter concisus d neg d d neg neg
    Campylobacter curvus neg d + + neg d
    Campylobacter gracilis neg neg d neg d d
    Campylobacter hominis neg neg neg + neg neg

  • Goossens, H., Pot, B., Vlaes, L., Van den Borre, C., Van den Abbeele, R., Van Naelten, C., Levy, J., Cogniau, H., Marbehant, P., & Verhoef, J. (1990). Characterization and description of “Campylobacter upsaliensis” isolated from human feces. Journal of Clinical Microbiology, 28(5), 1039–1046.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Proteobacteria Class:  Epsilonproteobacteria Order:  Campylobacterales Family:  Campylobacteraceae Genus:  Campylobacter Gram stain:  neg O2 Relation.:  microaerophilic Spore:  No spore Motility:  Swimming Morphology:  Rod - curved
    Health:  Unknown
    Source:  human faeces, clinical sources (blood - CCUG) and animals
    DNA G+C(%):  32-36
    Lower T(℃):  25(neg)
    Mid T(℃):  31(+)
    High T(℃):  42(+)
    NaCl 0.5-2%:  1.5(neg)
    Bile reaction(%):  2(+)
    		Urea:  neg Gelatin:  neg Starch:  neg Casein:  neg Tyrosine:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Mannose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Gly:  vr Hippurate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  neg Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg γ-Glu transf.:  neg GluDC:  neg AlanineAA:  neg GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  neg PyrrolidAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  neg EstLip(C8):  neg Lecithinase:  neg Lipase:  neg Lipase(C14):  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(0.06–0.5)
    ampicillin:  Sens
    carbenicil:  S(32)
    penicillin:  RNG: (1-32)
    piperacillin:  RNG: (2-26)
    piper-taz:  SensRNG: (0.016-4)
    tica-clav:  S(0.016)
    meropenem:  S(0.03)
    cefoperazone:  Sens
    cefoxitin:  RNG: (1-16)
    ceftizoxime:  SensRNG: (0.25-1)
    cephalothin:  S, MIC90: S, Var(2)
    gentamicin:  SensRNG: (2-4)
    kanamycin:  SensRNG: (0.5-2)
    neomycin:  RNG: (16-32)
    streptomycin:  SensRNG: (1-2)
    erythromycin:  SensRNG: (1-2)
    nalidixic-acid:  S(32)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    minocycline:  SensRNG: (<0.5-2)
    tetracycline:  SensRNG: (1-8)
    vancomycin:  R(>128)
    bacitracin:  R(>128)
    rifampicin:  RNG: (4-32)
    chloramphenicol:  SensRNG: (2-8)
    metronidazole:  R(4, vr)
    trimethoprim:  Sens
    clindamycin:  SensRNG: (0.25-0.5)
    colistin:  SensRNG: (0.5-1)
    polymyxin_B:  SensRNG: (0.25-1)

    References

    SPECIFIC REFERENCES FOR CAMPYLOBACTER UPSALIENSIS
  • Sandstedt1991 - Description of Campylobacter upsaliensis sp. nov. Previously Known as the CNW Group.
  • Vandamme1991 - Revision of Campylobacter, Helicobacter, and Wolinella Taxonomy: Emendation of Generic Descriptions and Proposal of Arcobacter gen. nov.
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CAMPYLOBACTER UPSALIENSIS
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • ...............................
    • GENERAL REFERENCES FOR CAMPYLOBACTER UPSALIENSIS
  • CCUG - Culture Collection University of Gothenburg - Entire Collection
  • VanDamme2005Bergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus I. Campylobacter
  • VanDamme2005aBergey - Bergey's manual of systematic bacteriology. Vol. 2, The Alpha-, Beta-, Delta-, and Epsilonproteobacteria Part C. Family Campylobacteraceae, Genus II. Arcobacter
    • Added: April 08, 2021