Capnocytophaga canimorsus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Capnocytophaga canimorsus is a Gram-negative, non-spore-forming, microaerophilic, gliding, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 36%. Capnocytophaga canimorsus is likely to be transient and not a long-term gut coloniser. (Brenner1989; Howell1990)



  • This organism has been recovered from a dog bite infection and septicemia. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: pathogen of humans and vertebrates). Is a known human pathogen. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • Mortality rate about 75% for patients with underlying disease.
    • GENERAL CHARACTERISTICS (Brenner1989);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • aesculin;
  • H+
  • Acid from carbohydrates usually produced:
  • galactose; glucose; mannose; dextrin; glycogen; starch; lactose; maltose;
  • ±
  • Strain-dependent acid from carbs:
  • fructose; cellubiose;
  • Active enzymes:
  • alkaline phosphatase; arginine dihydrolase; catalase; β-galactosidase; oxidase;
    • SPECIAL FEATURES (Brenner1989);
    Character Response
  • ✗
  • Metabolites not produced:
  • H₂S; indole;
  • ✗
  • Haemolysis:
  • absent
  • ✗
  • Nitrate:
  • not reduced
  • ±
  • Nitrite:
  • strain dependent
    • RESPONSE TO ANTIBIOTICS (Brenner1989); (Howell1990);
    Class Active Resistant
  • Penicillins:
  • ampicillin; carbenicillin; penicillin;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin; kanamycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • colistin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Flavobacteriia Order:  Flavobacteriales Family:  Flavobacteriaceae Genus:  Capnocytophaga Gram stain:  neg O2 Relation.:  microaerophilic Spore:  No spore Motility:  Gliding Morphology:  Rod
    Health:  Unknown
    Source:  a dog bite infection and septicemia
    DNA G+C(%):  36
    		Aesculin:  d Urea:  neg Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  d Galactose:  d(+) Glucose:  + Mannose:  d(+) Rhamnose:  neg Xylose:  neg Cellubiose:  d Lactose:  + Maltose:  + Melibiose:  neg Sucrose:  neg Trehalose:  neg Dextrin:  d(+) Glycogen:  d(+) Inulin:  neg Starch:  d(+) Adonitol:  neg Dulcitol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Citrate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  neg β-Galactosidase:  + ArgDH:  + LysDC:  neg OrnDC:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  Sens
    carbenicil:  Sens
    penicillin:  Sens
    cephalothin:  Sens
    gentamicin:  Res
    kanamycin:  Res
    erythromycin:  Sens
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    vancomycin:  Sens
    rifampicin:  Sens
    chloramphenicol:  Sens
    SXT:  Var
    clindamycin:  Sens
    colistin:  Res

    References

    SPECIFIC REFERENCES FOR CAPNOCYTOPHAGA CANIMORSUS
  • Brenner1989 - Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite.
  • Howell1990 - Precipitous hypotension in the emergency department caused by Capnocytophaga canimorsus sp nov sepsis.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CAPNOCYTOPHAGA CANIMORSUS
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • ...............................
    • Added: March 18, 2022