Cellulomonas hominis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Cellulomonas hominis is a Gram-positive, non-spore-forming, motile, short rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 73-76%. Cellulomonas hominis is probably a rare gut coloniser. (Brown2005; Funke1995; Stackebrandt2012Bergey)



  • This organism has been recovered from clinical sources (cerebrospinal fluid). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • Doesn't degrade cellulose
    • GENERAL CHARACTERISTICS (Brown2005); (Funke1995); (Stackebrandt2012Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; DNA; gelatin;
  • 🌡
  • Temperature tolerance:
  • grows at 35℃; grows at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; rhamnose; xylose; cellubiose; gentiobiose; lactose; maltose; sucrose; glycerol; gluconate; methyl mannoside; methyl xyloside; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • dextrin; gluconate; lactose; rhamnose; raffinose; xylose;
  • Active enzymes:
  • catalase; esterase C4; esterase lipase C8; α-glucosidase; Leu arylamidase;
    • SPECIAL FEATURES (Brown2005); (Funke1995); (Stackebrandt2012Bergey);
    Character Response
  • ✓
  • Nitrate:
  • reduced
  • Pigments:
  • light yellow
    • RESPONSE TO ANTIBIOTICS (Brown2005); (Funke1995);
    Class Active Resistant
  • Penicillins:
  • ampicillin;
  • Tetracyclines:
  • minocycline; tetracycline;
  • Aminoglycosides:
  • amikacin; gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • trimethoprim-sulfamethoxazole;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Micrococcales Family:  Cellulomonadaceae Genus:  Cellulomonas Gram stain:  + Spore:  No spore Motility:  Swimming Morphology:  Short Rod Pigment:  light yellow
    Health:  Unknown
    Source:  clinical sources (cerebrospinal fluid)
    DNA G+C(%):  73-76
    Mid T(℃):  35(+)
    High T(℃):  45(+)
    		Aesculin:  + Urea:  neg Gelatin:  + DNA:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  + Xylose:  + Cellubiose:  + Gentiobiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Cellulose:  neg Adonitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  + Inositol:  neg Mannitol:  neg Sorbitol:  neg Gluconate:  + 2-Ketogluconate:  neg Me-α-D-Mann:  + Me-Xyloside:  + Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Rhamnose:  + Ribose:  neg Xylose:  + Lactose:  + Raffinose:  + Dextrin:  + Gluconate:  + Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg α-Fucosidase:  neg α-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  w Chymotrypsin:  neg LeuAA:  + ValAA:  neg AlkalineP:  neg Esterase(C4):  + EstLip(C8):  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Pigment:  light yellow
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Var(MIC50): 2, MIC90: 4
    ampicillin:  R(4-8)
    penicillin_G:  Var(MIC50): 1-2), MIC90: Var(1-2
    imipenem:  Var(MIC50): 2), MIC90: Var(2
    amikacin:  R(>32)
    gentamicin:  R(8-16)
    erythromycin:  Var(MIC50): 1-2), MIC90: Var(1-2
    clarithromycin:  Var(MIC50): 2), MIC90: Var(2
    ciprofloxacin:  Var(MIC50): 1-4), MIC90: Var(1-4
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    minocycline:  S(0.13)
    tetracycline:  SensRNG: (0.25-0.5)
    vancomycin:  (0.06-0.125)
    rifampicin:  S(0.03)
    SXT:  R(>8)
    clindamycin:  Var(MIC50): 0.25-8), MIC90: Var(0.25-8

    References

    SPECIFIC REFERENCES FOR CELLULOMONAS HOMINIS
  • Brown2005 - Phenotypic and Genetic Characterization of Clinical Isolates of CDC Coryneform Group A-3: Proposal of a New Species of Cellulomonas , Cellulomonas denverensis sp. nov.
  • Funke1995 - Identification of some clinical strains of CDC coryneform group A-3 and A-4 bacteria as Cellulomonas species and proposal of Cellulomonas hominis sp. nov. for some group A-3 strains.
  • Stackebrandt2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Cellulomonadaceae, Genus I. Cellulomonas
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CELLULOMONAS HOMINIS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
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    • Added: January 14, 2022