Cellulosilyticum lentocellum

(aka Clostridium lentocellum)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Cellulosilyticum lentocellum, (aka Clostridium lentocellum), is a Gram-negative, spore-forming, strictly anaerobic, motile, rod-shaped - curved bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 36%. Cellulosilyticum lentocellum is probably a rare gut coloniser. (Cai2010)



  • This organism has been recovered from human faeces, and domestic effluent and mud. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • Cellulolytic.
    • GENERAL CHARACTERISTICS (Cai2010);
    Character Response
  • Substrates hydrolysed or digested:
  • cellulose;
  • pH
  • Acidity tolerance:
  • tolerates pH 5.7; tolerates pH 9.1; Grows optimally at pH 7.5-7.7.
  • 🌡
  • Temperature tolerance:
  • grows at 15℃; grows at 46.5℃; Grows optimally at 40℃.
  • ⥅
  • Substrates assimilated or utilised:
  • arabinose; cellubiose; cellulose; aesculin; fructose; galactose; glucose; glycogen; lactose; maltose; salicin; starch; sucrose; trehalose; xylose; pyruvate;
    • SPECIAL FEATURES (Cai2010);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate (major); lactate (minor); ethanol; succinate (minor); COâ‚‚; Hâ‚‚;
  • ✗
  • Metabolites not produced:
  • butyrate; indole;
  • ✗
  • Nitrate:
  • not reduced

  • Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., … Zhao, L. (2008). Symbiotic gut microbes modulate human metabolic phenotypes. Proceedings of the National Academy of Sciences of the United States of America, 105(6), 2117–2122.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Cellulosilyticum Alt. name:  Clostridium lentocellum Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod - curved
    Health:  Unknown
    Source:  human faeces, and domestic effluent and mud
    DNA G+C(%):  36
    Opt. T:  40℃
    Low T(℃):  15(+)
    High T(℃):  46.5(+)
    Opt. pH:  7.5-7.7
    pH 4.2-5.9:  5.7(+)
    pH >8:  9.1(+)
    		Gelatin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  + Fructose:  + Galactose:  + Glucose:  + Mannose:  neg Rhamnose:  neg Ribose:  neg Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  neg Melibiose:  neg Raffinose:  neg Sucrose:  + Trehalose:  + Adonitol:  neg Amygdalin:  neg Cellulose:  + Aesculin:  + Glycogen:  + Inositol:  neg Inulin:  neg Mannitol:  neg Salicin:  + Sorbitol:  neg Starch:  + Arg:  neg Hippurate:  neg Thr:  neg Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg Urease:  w
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  Major(+) Butyrate:  neg Lactate:  minor(+) Ethanol:  + Succinate:  minor(+) CO2:  + H2:  + Indole:  neg

    References

    SPECIFIC REFERENCES FOR CELLULOSILYTICUM LENTOCELLUM
  • Cai2010 - Cellulosilyticum ruminicola gen. nov., sp. nov., isolated from the rumen of yak, and reclassification of Clostridium lentocellum as Cellulosilyticum lentocellum comb. nov.
  • Chua2018 - Intestinal Dysbiosis Featuring Abundance of Ruminococcus gnavus Associates With Allergic Diseases in Infants
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CELLULOSILYTICUM LENTOCELLUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Qin2012 - Metagenome-wide association study of gut microbiota in type 2 diabetes
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR CELLULOSILYTICUM LENTOCELLUM
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021