Cellulosimicrobium cellulans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Cellulosimicrobium cellulans is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, club-shaped-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 74%. Cellulosimicrobium cellulans is probably a rare gut coloniser. (Schumann2001)



  • This organism has been recovered from human faeces and clinical sources (CCUG). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Could be a possible pathogen in humans, but unknown at this stage. Is a known gut commensal.
    • QUIRKS
  • Cellulolytic.
    • GENERAL CHARACTERISTICS (Schumann2001);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; starch; xanthine; cellulose;
  • H+
  • Acid from carbohydrates usually produced:
  • arabinose; fructose; glucose; mannose; ribose; xylose; glycogen; cellubiose; maltose; sucrose; D-turanose; N-Ac glucosamine;
  • ⥅
  • Substrates assimilated or utilised:
  • L-arabinose; cellubiose; cellulose; gluconate; glucose; glycerol; inositol; lactose; maltose; mannitol; mannose; ribose; sucrose; xylose; aspartate; histidine; proline; caproate; caprylate; heptanoate; propionate; pyruvate; valerate; L-asparagine; L-lactate;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; N-Ac β-glucosaminidase; catalase; esterase C4; esterase lipase C8; β-galactosidase; α-glucosidase; β-glucosidase; Leu arylamidase; pyrrolidine arylamidase;
    • SPECIAL FEATURES (Schumann2001);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate (major); lactate; ethanolminor; CO₂;
  • ✗
  • VP test:
  • not active
  • ✓
  • NO3➔NO2:
  • reduced

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Micrococcales Family:  Promicromonosporaceae Genus:  Cellulosimicrobium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Club rod
    Health:  Unknown
    Source:  human faeces and clinical sources (CCUG)
    DNA G+C(%):  74
    		Aesculin:  + Urea:  neg Gelatin:  w Starch:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  + Fructose:  + Glucose:  + Mannose:  + Ribose:  + Xylose:  + Cellubiose:  + Lactose:  neg Maltose:  + Sucrose:  + Turanose:  + Glycogen:  + Mannitol:  neg NAc-α-GA:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    L-Arabinose:  + Glucose:  + Mannose:  + Ribose:  + Xylose:  + Cellubiose:  + Lactose:  + Maltose:  + Raffinose:  neg Sucrose:  + Cellulose:  + Gluconate:  + Glycerol:  + Inositol:  + Mannitol:  + Asp:  + His:  + Pro:  + Caproate:  + Caprylate:  + Heptanoate:  + L-Malate:  neg Propionate:  + Pyruvate:  + Valerate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg OrnDC:  neg LeuAA:  + PyrrolidAA:  + AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg

    References

    SPECIFIC REFERENCES FOR CELLULOSIMICROBIUM CELLULANS
  • Schumann2001 - Reclassification of Cellulomonas cellulans (Stackebrandt and Keddie 1986) as Cellulosimicrobium cellulans gen. nov., comb. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CELLULOSIMICROBIUM CELLULANS
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Pfleiderer2013 - Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021