Cloacibacillus porcorum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Cloacibacillus porcorum is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped - curved bacterium. It has been detected in at least 6 gut microbiome compilation studies or metastudies. The DNA G+C content is 55.1%. Cloacibacillus porcorum is probably a rare gut coloniser. (Domingo2015; Looft2013)



  • This organism has been recovered from human faeces (Bilen2018e), clinical sources (blood - CCUG) and pig intestines. Could be a possible pathogen in humans, but unknown at this stage. A possible gut commensal.
    • QUIRKS
  • Ferments mucin to formate, acetate and propionate.
    • GENERAL CHARACTERISTICS (Looft2013);
    Character Response
  • Substrates hydrolysed or digested:
  • mucin;
  • 🧂
  • Salt tolerance:
  • tolerates 1.4% salt; Grows optimally with 0.6-0.8% salt.
  • pH
  • Acidity tolerance:
  • tolerates pH 4.2; tolerates pH 8.0; Grows optimally at pH 6.5.
  • 🌡
  • Temperature tolerance:
  • grows at 20℃; grows at 45℃; Grows optimally at 39℃.
  • ⥅
  • Substrates assimilated or utilised:
  • N-acetylglucosamine; fucose; galactose; mannose; arginine; cysteine; histidine; proline; serine; threonine; tryptophan; N-acetylgalactosamine; N-acetylneuraminic acid; mucin;
  • Active enzymes:
  • acid phosphatase; arginine dihydrolase; esterase C4; esterase lipase C8; glutamic acid decarboxylase; Leu arylamidase; naphthol-ASBI-P;
    • SPECIAL FEATURES (Looft2013);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate; propionate; butyrate;
    • RESPONSE TO ANTIBIOTICS (Domingo2015); (Looft2013);
    Class Active Resistant
  • Penicillins:
  • meropenem; penicillin; piperacillin-tazobactam;
  • Cephalosporins:
  • cefoxitin;
  • Tetracyclines:
  • chlortetracycline;
  • Heterocycles:
  • metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; lincomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Synergistetes Class:  Synergistia Order:  Synergistales Family:  Synergistaceae Genus:  Cloacibacillus Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod - curved
    Health:  Unknown
    Source:  human faeces (Bilen2018e), clinical sources (blood - CCUG) and pig intestines
    DNA G+C(%):  55.1
    Opt. T:  39℃
    Lower T(℃):  20(+)
    High T(℃):  45(+)
    NaCl 0.5-2%:  1.4(+)
    Opt. pH:  6.5
    pH 4.2-5.9:  4.2(+)
    pH 6.0-8.0:  8.0(+)
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Fucose:  + Galactose:  + Glucose:  neg Mannose:  + N_Acetyl_glucosamine:  + Glucosamine:  neg Ala:  neg Arg:  + Asp:  neg Cys:  + Glu:  neg Gly:  neg His:  + Ile:  neg Leu:  neg Lys:  neg Met:  neg Phe:  neg Pro:  + Ser:  + Thr:  + Trp:  + Tyr:  neg Val:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  neg ArgDH:  + GluDC:  + LeuAA:  + ProAA:  w AlkalineP:  w AcidP:  + Esterase(C4):  + EstLip(C8):  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin:  S(0.125)
    piper-taz:  S(2/4)
    meropenem:  S(0.03)
    cefoxitin:  S(2)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    chlortetracycline:  S(<4)
    vancomycin:  R(512)
    metronidazole:  S(0.5)
    clindamycin:  S(0.5)
    lincomycin:  S(<4)

    References

    SPECIFIC REFERENCES FOR CLOACIBACILLUS PORCORUM
  • Domingo2015 - Cloacibacillus sp., a Potential Human Pathogen Associated with Bacteremia in Quebec and New Brunswick.
  • Looft2013 - Cloacibacillus porcorum sp. nov., a mucin-degrading bacterium from the swine intestinal tract and emended description of the genus Cloacibacillus.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CLOACIBACILLUS PORCORUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • New2022 - Collective effects of human genomic variation on microbiome function.
  • Wang2020a - Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • ...............................
    • GENERAL REFERENCES FOR CLOACIBACILLUS PORCORUM
  • Bilen2018e - Description of the human gut microbiota by culturomics
    • Added: December 15, 2021