Clostridioides mangenotii

(aka Clostridium mangenotii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Clostridioides mangenotii, (aka Clostridium mangenotii), is a Gram-positive, spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 31.6%. Clostridioides mangenotii is probably a rare gut coloniser. (Lawson2016; Rainey2011fBergey)



  • This organism has been recovered from human faeces (Rainey2011fBergey), soil and marine sediments. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Is a known human pathogen. Is a known gut commensal.
    • QUIRKS
  • Produces 5-aminovalerate and 2-aminobutyrate.
    • GENERAL CHARACTERISTICS (Lawson2016); (Rainey2011fBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • meat;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 6.5% salt;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 8.5.
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 40℃; doesn't grow at 45℃; Grows optimally at 30-37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • glucose;
  • ⥅
  • Substrates assimilated or utilised:
  • isoleucine; leucine; phenylalanine; proline; threonine; tryptophan; tyrosine; valine; pyruvate;
    • SPECIAL FEATURES (Lawson2016); (Rainey2011fBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate (minor); acetate (major); propionate (minor); isobutyrate (minor); isovalerate (minor); H₂S; H₂; indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Lawson2016);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Heterocycles:
  • chloramphenicol;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Peptostreptococcaceae Genus:  Clostridioides Alt. name:  Clostridium mangenotii Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces (Rainey2011fBergey), soil and marine sediments
    DNA G+C(%):  31.6
    Opt. T:  30-37℃
    Lower T(℃):  25(+)
    Mid T(℃):  40(+)
    High T(℃):  45(neg)
    NaCl >6%:  6.5(neg)
    Opt. pH:  8.5
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Urea:  neg Milk:  d Meat:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  + Lactose:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Inositol:  neg Ile:  + Leu:  + Phe:  + Pro:  + Thr:  + Trp:  + Tyr:  + Val:  + Lactate:  neg Pyruvate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Lecithinase:  neg Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  minor(+) Acetate:  Major(+) Propionate:  minor(+) Isobutyrate:  minor(+) Isovalerate:  minor(+) H2S:  + H2:  + Indole:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  Sens
    erythromycin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    chloramphenicol:  Sens
    clindamycin:  Sens

    References

    SPECIFIC REFERENCES FOR CLOSTRIDIOIDES MANGENOTII
  • Lawson2016 - Reclassification of Clostridium difficile as Clostridioides difficile (Hall and O'Toole 1935) Prevot 1938.
  • Rainey2011fBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster XI
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CLOSTRIDIOIDES MANGENOTII
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • ...............................
    • GENERAL REFERENCES FOR CLOSTRIDIOIDES MANGENOTII
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: July 25, 2021