Clostridium saudiense

(aka Clostridium saudii)

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Clostridium saudiense, (aka Clostridium saudii), is a Gram-positive, spore-forming, strictly anaerobic, motile, rod-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 28%. Clostridium saudiense is probably a common, although minor, coloniser of the gut. (Angelakis2014)



  • This organism has been recovered from human faeces and clinical sources (blood - CCUG). Is a rare opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • In 54% of Europeans (unseenbio.com). Minor coloniser.
    • GENERAL CHARACTERISTICS (Angelakis2014);
    Character Response
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • Active enzymes:
  • Ala arylamidase; arabinosidase; Arg arylamidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; Gly arylamidase; His arylamidase; pyroGlu arylamidase; Tyr arylamidase;
    • SPECIAL FEATURES (Angelakis2014);
    Character Response
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Angelakis2014);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; imipenem;
  • amoxicillin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • metronidazole; trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Clostridium Alt. name:  Clostridium saudii Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Swimming Morphology:  Rod
    Health:  Unknown
    Source:  human faeces and clinical sources (blood - CCUG)
    DNA G+C(%):  28
    Opt. T:  37℃
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Mannose:  neg Raffinose:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  neg Urease:  neg α-Arab:  + α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  neg ArgDH:  neg GluDC:  neg AlanineAA:  + ArgAA:  + GluGluAA:  neg GlyAA:  + HisAA:  + LeuAA:  neg LeuGlyAA:  neg ProAA:  neg PheAA:  neg PyrogluAA:  + SerAA:  neg TyrAA:  + AlkalineP:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  Res
    Augmentin:  Sens
    imipenem:  Sens
    gentamicin:  Res
    erythromycin:  Res
    ciprofloxacin:  Res
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  Sens
    vancomycin:  Sens
    rifampicin:  Sens
    metronidazole:  Sens
    SXT:  Sens

    References

    SPECIFIC REFERENCES FOR CLOSTRIDIUM SAUDIENSE
  • Angelakis2014 - Non-contiguous finished genome sequence and description of Clostridium saudii sp. nov.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CLOSTRIDIUM SAUDIENSE
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chung2016 - Modulation of the human gut microbiota by dietary fibres occurs at the species level.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • ...............................
    • GENERAL REFERENCES FOR CLOSTRIDIUM SAUDIENSE
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: July 12, 2021