Clostridium sporosphaeroides

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Clostridium sporosphaeroides is a Gram-positive, spore-forming, strictly anaerobic, non-motile, bacterium. It has been detected in at least 8 gut microbiome compilation studies or metastudies. The DNA G+C content is 27%. Clostridium sporosphaeroides is probably a common, although minor, coloniser of the gut. (Yutin2013; Rainey2011dBergey)



  • This organism has been recovered from human faeces and canned food. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Yutin2013); (Rainey2011dBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • hippurate;
  • 🧂
  • Salt tolerance:
  • doesn't tolerate 6.5% salt;
  • 💧
  • Bile tolerance:
  • Doesn't tolerate 20% bile
  • 🌡
  • Temperature tolerance:
  • grows weakly at 30℃; grows at 37℃; grows at 45, 60(neg)℃; Grows optimally at 37–45℃.
  • ⥅
  • Substrates assimilated or utilised:
  • glutamate; lactate; pyruvate; glutamine;
    • SPECIAL FEATURES (Yutin2013); (Rainey2011dBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate (minor); butyrate; H₂S; ammonia; CO₂; H₂;
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Haemolysis:
  • absent

  • Moore, WEC & LV Holdeman (1974). Human fecal flora: the normal flora of 20 Japanese-Hawaiians. Appl. Microbiol. 27: 961-979.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Clostridiaceae Genus:  Clostridium Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile
    Health:  Unknown
    Source:  human faeces and canned food
    DNA G+C(%):  27
    Opt. T:  37–45℃
    Lower T(℃):  30(w)
    Mid T(℃):  37(+)
    High T(℃):  45(+), 60(neg)
    NaCl >6%:  6.5(neg)
    Bile reaction(%):  20(neg)
    		Aesculin:  neg Starch:  neg Hippurate:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Sorbose:  neg Adonitol:  neg Dulcitol:  neg Erythritol:  neg Glu:  + Phe:  neg Thr:  neg Trp:  neg Tyr:  neg Lactate:  + Pyruvate:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  minor(+) Butyrate:  + H2S:  + Ammonia:  + CO2:  + H2:  + Indole:  neg

    References

    SPECIFIC REFERENCES FOR CLOSTRIDIUM SPOROSPHAEROIDES
  • Yutin2013 - A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia.
  • Rainey2011dBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Clostridiaceae, Genus I. Clostridium - Cluster IV
  • Dong2020a - The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CLOSTRIDIUM SPOROSPHAEROIDES
  • Benno1984 - The intestinal microflora of infants: composition of fecal flora in breast-fed and bottle-fed infants.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Finegold1974 - Effect of diet on human fecal flora: comparison of Japanese and American diets
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Moore1974 - Human fecal flora: the normal flora of 20 Japanese-Hawaiians.
  • PerisBondia2011 - The active human gut microbiota differs from the total microbiota.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Woodmansey2004 - Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects.
  • ...............................
    • GENERAL REFERENCES FOR CLOSTRIDIUM SPOROSPHAEROIDES
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: April 08, 2021