Coprobacter fastidiosus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Coprobacter fastidiosus is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 10 gut microbiome compilation studies or metastudies. The DNA G+C content is 38.5%. Coprobacter fastidiosus is a common gut coloniser. (Shkoporov2013)



  • This organism has been recovered from human faeces (Shkoporov2013). Pathogenicity status unknown, or very unlikely to be pathogenic. A possible gut commensal.
    • QUIRKS
  • In 87% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Shkoporov2013);
    Character Response
  • Substrates hydrolysed or digested:
  • gelatin;
  • 💧
  • Bile tolerance:
  • Resistant to 2% bile
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; lactose; maltose; raffinose;
  • ⥅
  • Substrates assimilated or utilised:
  • glucose; lactose; maltose; mannose; raffinose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; N-Ac β-glucosaminidase; catalase; α-galactosidase; β-galactosidase; α-glucosidase; glutamic acid decarboxylase; Leu-Gly arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • arginine dihydrolase; β-glucuronidase;
    • SPECIAL FEATURES (Shkoporov2013);
    Character Response
  • ✓
  • Metabolites produced:
  • acetate; propionate; succinate (minor);
  • ✗
  • Metabolites not produced:
  • indole;
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • Pigments:
  • not produced
    • RESPONSE TO ANTIBIOTICS (Shkoporov2013);
    Class Active Resistant
  • Penicillins:
  • ampicillin; oxacillin; penicillin G;
  • Cephalosporins:
  • cefoperazone; cefoxitin; cefuroxime; cephalothin;
  • ceftazidime;
  • Macrolides:
  • azithromycin;
  • Tetracyclines:
  • doxycycline;
  • Quinolines:
  • levofloxacin;
  • Aminoglycosides:
  • amikacin; gentamicin;
  • Heterocycles:
  • chloramphenicol; co-trimoxazole; fusidic-acid; metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin;
  • NOTES

    This is a recently discovered inhabitant of the human gut.

    Fuel sources used:
    It can use fibre, simple sugars (including lactose) and protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, BCAAs, GABA, lactate, LPS, propionate, succinate, folate, biotin, riboflavin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

  • References: [1] [2]

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacteroidales Family:  Porphyromonadaceae Genus:  Coprobacter Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod Pigment:  neg
    Health:  Unknown
    Source:  human faeces (Shkoporov2013)
    DNA G+C(%):  38.5
    Mid T(℃):  37(+)
    Bile reaction(%):  2(+)
    		Aesculin:  neg Urea:  neg Gelatin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  neg Cellubiose:  neg Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  neg Trehalose:  neg Glycogen:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Glucose:  + Mannose:  + Lactose:  + Maltose:  + Raffinose:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg Ac-β-glcamnd:  + α-Fucosidase:  neg α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  d ArgDH:  d GluDC:  + AlanineAA:  + GluGluAA:  neg GlyAA:  neg LeuAA:  neg LeuGlyAA:  + PyrrolidAA:  neg AlkalineP:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Acetate:  + Propionate:  + Succinate:  minor(+) Indole:  neg Pigment:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  R(10; disc)
    cloxacillin:  I(10; disc)
    oxacillin:  R(1; disc)
    penicillin_G:  R(10U)
    cefoperazone:  S(75; disc)
    cefoxitin:  S(30; disc)
    ceftazidime:  R(30; disc)
    cefuroxime:  S(30; disc)
    cephalothin:  S(30; disc)
    amikacin:  R(30; disc)
    gentamicin:  R(10; disc)
    azithromycin:  S(15; disc)
    ciprofloxacin:  I(5; disc)
    levofloxacin:  S(5; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(30; disc)
    vancomycin:  S(30; disc)
    chloramphenicol:  S(10; disc)
    metronidazole:  S(5; disc)
    co-trimoxazole:  S(25; disc)
    clindamycin:  S(2; disc)
    fusidic-acid:  S(10; disc)

    References

    SPECIFIC REFERENCES FOR COPROBACTER FASTIDIOSUS
  • Shkoporov2013 - Coprobacter fastidiosus gen. nov., sp. nov., a novel member of the family Porphyromonadaceae isolated from infant faeces.
  • Dong2020a - The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls
  • Kim2020a - Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
  • Malham2019 - The microbiome reflects diagnosis and predicts disease severity in paediatric onset inflammatory bowel disease
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR COPROBACTER FASTIDIOSUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
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    • Added: February 08, 2021