Coprobacter secundus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Coprobacter secundus is a Gram-negative, non-spore-forming, strictly anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 37.8%. Coprobacter secundus is a common gut coloniser. (Shkoporov2015; Sakamoto2021a)



  • This organism has been recovered from human faeces (Shkoporov2015). Pathogenicity status unknown, or very unlikely to be pathogenic. Likely to be transient and not a long-term gut commensal.
    • QUIRKS
  • In 73% of Europeans (unseenbio.com).
    • GENERAL CHARACTERISTICS (Shkoporov2015); (Sakamoto2021a);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin; gelatin;
  • 💧
  • Bile tolerance:
  • Resistant to 20% bile
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • glucose; mannose; rhamnose; cellubiose; lactose; maltose; raffinose; sucrose; trehalose;
  • Active enzymes:
  • Ala arylamidase; alkaline phosphatase; N-Ac β-glucosaminidase; catalase; fucosidase; α-galactosidase; β-galactosidase; α-glucosidase; β-glucosidase; β-glucuronidase; Leu-Gly arylamidase;
    • SPECIAL FEATURES (Shkoporov2015); (Sakamoto2021a);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate (major); succinate;
    • RESPONSE TO ANTIBIOTICS (Shkoporov2015);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid;
  • cloxacillin; oxacillin; penicillin G;
  • Cephalosporins:
  • ceftazidime; cephalothin;
  • Macrolides:
  • roxithromycin;
  • Quinolines:
  • levofloxacin;
  • moxifloxacin;
  • Aminoglycosides:
  • neomycin;
  • Heterocycles:
  • fusidic-acid; metronidazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • clindamycin; linezolid;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Bacteroidetes Class:  Bacteroidia Order:  Bacillales Family:  Barnesiellaceae Genus:  Coprobacter Gram stain:  neg O2 Relation.:  strictly anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  human faeces (Shkoporov2015)
    DNA G+C(%):  37.8
    Mid T(℃):  37(+)
    Bile reaction(%):  20(+)
    		Aesculin:  + Gelatin:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Glucose:  + Mannose:  + Rhamnose:  + Xylose:  neg Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  neg Sucrose:  + Trehalose:  + Glycerol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  w
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Ac-β-glcamnd:  + α-Fucosidase:  + α-Galactosidase:  + β-Galactosidase:  + α-Glucosidase:  + β-Glucosidase:  + β-Glucuronidase:  + GluDC:  neg AlanineAA:  + LeuGlyAA:  + AlkalineP:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  S(30; disc)
    cloxacillin:  R(10; disc)
    oxacillin:  R(1; disc)
    penicillin_G:  R(10U)
    ceftazidime:  R(30; disc)
    cephalothin:  R(30; disc)
    amikacin:  I(30; disc)
    gentamicin:  I(10; disc)
    neomycin:  R(10; disc)
    roxithromycin:  S(30; disc)
    linezolid:  S(30; disc)
    levofloxacin:  S(5; disc)
    moxifloxacin:  R(5; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    vancomycin:  S(30; disc)
    metronidazole:  S(5; disc)
    clindamycin:  S(2; disc)
    fusidic-acid:  S(10; disc)

    References

    SPECIFIC REFERENCES FOR COPROBACTER SECUNDUS
  • Shkoporov2015 - Alistipes inops sp. nov. and Coprobacter secundus sp. nov., isolated from human faeces.
  • Sakamoto2021a - Coprobacter secundus subsp. similis subsp. nov. and Solibaculum mannosilyticum gen. nov., sp. nov., isolated from human feces
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR COPROBACTER SECUNDUS
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Yang2020 - Species-Level Analysis of Human Gut Microbiota With Metataxonomics.
  • Yang2020a - Establishing high-accuracy biomarkers for colorectal cancer by comparing fecal microbiomes in patients with healthy families
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    • Added: July 12, 2021