Coprococcus eutactus

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Coprococcus eutactus is a Gram-positive, spore-forming, strictly anaerobic, non-motile, coccus bacterium. It has been detected in at least 28 gut microbiome compilation studies or metastudies. The DNA G+C content is 41%. Coprococcus eutactus is often a widespread coloniser of gut. (Browne2016; Holdeman1974; Ezaki2011dBergey)



  • This organism has been recovered from human faeces. The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread. Pathogenicity status unknown, or very unlikely to be pathogenic. Is a known gut commensal. Robust growth can have positive consequences for gut health.
    • GENERAL CHARACTERISTICS (Holdeman1974); (Ezaki2011dBergey);
    Character Response
  • Substrates hydrolysed or digested:
  • aesculin;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • milk;
  • 🌡
  • Temperature tolerance:
  • grows weakly at 30℃; grows at 37℃; grows at 45℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; mannose; amygdalin; starch; cellubiose; lactose; maltose; melezitose; melibiose; raffinose; sucrose; salicin;
  • ⥅
  • Substrates assimilated or utilised:
  • cellubiose; glucose; lactose; maltose; mannose; raffinose; sucrose;
    • SPECIAL FEATURES (Holdeman1974); (Ezaki2011dBergey);
    Character Response
  • ✓
  • Metabolites produced:
  • formate; acetate (minor); butyrate; lactate (minor); succinate (trace); pyruvate (trace);
  • ✗
  • Metabolites not produced:
  • ethanol; Hâ‚‚S; ammonia;
  • ✓
  • VP test:
  • active
  • ✗
  • Haemolysis:
  • absent
  • NOTES

    This is a common inhabitant of the human gut.

    Fuel sources used:
    It can use fibre, simple sugars (including lactose) and limited types of protein for energy.

    Metabolites produced:
    Our genomic analysis indicates that most members of this species can produce the following metabolites: acetate, BCAAs, butyrate, lactate, propionate, folate, biotin, riboflavin.

    Metabolites consumed:
    In addition, our genomic analysis indicates that most members of this species do not consume any reported metabolites.

    Emerging research:
    This species has been observed at decreased levels in individuals with asthma, children with type 1 diabetes and children with Crohn's disease.

  • References: [1] [2] [3] [4] [5] [6]

  • Holdeman, L. V., & Moore, W. E. C. (1974). New genus, Coprococcus, twelve new species, and emended descriptions of four previously described species of bacteria from human feces. International Journal of Systematic Bacteriology, 24(2), 260–277.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Firmicutes Class:  Clostridia Order:  Eubacteriales Family:  Lachnospiraceae Genus:  Coprococcus Gram stain:  + O2 Relation.:  strictly anaerobic Spore:  Endospore Motility:  Sessile Morphology:  Coccus
    Health:   Positive
    Source:  human faeces
    DNA G+C(%):  41
    Lower T(℃):  30(w)
    Mid T(℃):  37(+)
    High T(℃):  45(+)
    		Aesculin:  + Starch:  vr Hippurate:  neg Milk:  curdle
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg Fructose:  + Glucose:  + Mannose:  + Ribose:  neg Sorbose:  neg Xylose:  neg Cellubiose:  + Lactose:  + Maltose:  + Melezitose:  + Melibiose:  + Sucrose:  + Trehalose:  neg Amygdalin:  + Aesculin:  vr Inulin:  neg Starch:  + Adonitol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  +
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Glucose:  + Mannose:  + Xylose:  neg Cellubiose:  + Lactose:  + Maltose:  + Raffinose:  + Sucrose:  + Mannitol:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Formate:  + Acetate:  minor(+) Butyrate:  + Lactate:  minor(+) Ethanol:  neg Succinate:  trace(+) H2S:  neg Pyruvate:  trace(+) Ammonia:  neg

    References

    SPECIFIC REFERENCES FOR COPROCOCCUS EUTACTUS
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Holdeman1974 - New Genus, Coprococcus, Twelve New Species, and Emended Descriptions of Four Previously Described Species of Bacteria from Human Feces.
  • Ezaki2011dBergey - Bergey's manual of systematic bacteriology. Vol. 3, The Firmicutes. Family Lachnospiraceae, Genus VII. Coprococcus
  • Petrov2017 - Analysis of Gut Microbiota in Patients with Parkinson's Disease.
  • Salyers1977 - Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon
  • DeAngelis2013 - Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  • deGoffau2014 - Aberrant gut microbiota composition at the onset of type 1 diabetes in young children
  • Dong2020a - The Association of Gut Microbiota With Idiopathic Central Precocious Puberty in Girls
  • Hedin2015 - Siblings of patients with Crohn's disease exhibit a biologically relevant dysbiosis in mucosal microbial metacommunities
  • Huang2019 - Analysis of microbiota in elderly patients with Acute Cerebral Infarction
  • Kassinen2007 - The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects
  • Kim2020a - Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2011 - Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome
  • Wang2019b - Alterations in the human gut microbiome associated with Helicobacter pylori infection
  • Nylund2015 - Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR COPROCOCCUS EUTACTUS
  • Benno1986 - Comparison of the fecal microflora in rural Japanese and urban Canadians.
  • Browne2016 - Culturing of 'unculturable' human microbiota reveals novel taxa and extensive sporulation.
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Chen2020 - Structural and Functional Characterization of the Gut Microbiota in Elderly Women With Migraine
  • Chen2020a - Featured Gut Microbiomes Associated With the Progression of Chronic Hepatitis B Disease
  • Dubinkina2017 - Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Hu2019 - The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Jie2017 - The gut microbiome in atherosclerotic cardiovascular disease
  • Karlsson2013 - Gut metagenome in European women with normal, impaired and diabetic glucose control
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • LeChatelier2013 - Richness of human gut microbiome correlates with metabolic markers
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • Minerbi2019 - Altered microbiome composition in individuals with fibromyalgia
  • Moore1974 - Human fecal flora: the normal flora of 20 Japanese-Hawaiians.
  • Nielsen2014 - MetaHIT Consortium. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • PerisBondia2011 - The active human gut microbiota differs from the total microbiota.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • Rothschild2018 - Environment dominates over host genetics in shaping human gut microbiota.
  • Salonen2014 - Impact of diet and individual variation on intestinal microbiota composition and fermentation products in obese men.
  • Tyakht2013 - Human gut microbiota community structures in urban and rural populations in Russia.
  • Walker2011 - High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease.
  • Wang2018 - A metagenome-wide association study of gut microbiota in asthma in UK adults
  • Wang2018a - Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • Zou2019 - 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses.
  • Zupancic2012 - Analysis of the Gut Microbiota in the Old Order Amish and Its Relation to the Metabolic Syndrome.
  • ...............................
    • GENERAL REFERENCES FOR COPROCOCCUS EUTACTUS
  • Ludwig2009 - Revised road map to the phylum Firmicutes.
    • Added: February 08, 2021