Corynebacterium accolens

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium accolens is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 58.2%. Corynebacterium accolens is probably a rare gut coloniser. (Neubauer1991; Bernard2012Bergey)



  • This organism has been recovered from clinical sources (inflammatory foci, blood, wound, vaginal discharge - CCUG). Has been detected in human faeces (Bilen2018e). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Neubauer1991); (Bernard2012Bergey);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • urea;
  • pH
  • Acidity tolerance:
  • Grows optimally at pH 7.2.
  • 🌡
  • Temperature tolerance:
  • grows at 30℃; grows at 40℃; Grows optimally at 37℃.
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; maltose;
  • ±
  • Strain-dependent acid from carbs:
  • sucrose;
  • Active enzymes:
  • catalase;
  • ±
  • Strain-dependent active enzymes:
  • urease;
    • SPECIAL FEATURES (Neubauer1991);
    Character Response
  • ✗
  • Metabolites not produced:
  • Hâ‚‚S; indole;
  • ✗
  • Methyl red test:
  • not active
  • ✗
  • VP test:
  • not active
  • ✓
  • NO3➔NO2:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Neubauer1991); (Tyrrell2012); (Goldstein2008); (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • ampicillin; ampicillin-sulbactam; doripenem; ertapenem; imipenem; meropenem; oxacillin; penicillin; penicillin G;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline;
  • Quinolines:
  • levofloxacin; moxifloxacin;
  • Aminoglycosides:
  • gentamicin; kanamycin; neomycin; streptomycin;
  • Heterocycles:
  • chloramphenicol;
  • sulfadimethoxine;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid; polymyxin B;
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  clinical sources (inflammatory foci, blood, wound, vaginal discharge - CCUG). Has been detected in human faeces (Bilen2018e)
    DNA G+C(%):  58.2
    Opt. T:  37℃
    Lower T(℃):  30(+)
    Mid T(℃):  40(+)
    Opt. pH:  7.2
    		Aesculin:  neg Urea:  d(neg) Gelatin:  neg Starch:  neg Casein:  neg Milk:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    L-Arabinose:  neg Fructose:  + Galactose:  + Glucose:  + Mannose:  + Rhamnose:  neg Xylose:  neg Lactose:  neg Maltose:  + Sucrose:  d Trehalose:  neg Inulin:  neg Dulcitol:  neg Glycerol:  neg Inositol:  neg Mannitol:  neg Sorbitol:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Citrate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Urease:  d(neg) Lipase:  neg
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		H2S:  neg Indole:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 1, MIC90: >32, RNG: (0.03–32)
    amp-sulb:  S(MIC50): 0.5, MIC90: 2, RNG: (0.015–2)
    oxacillin:  S(15; disc)
    penicillin:  S(10U)
    penicillin_G:  S(MIC50): 1, MIC90: 1, RNG: (0.125–1)
    piper-taz:  Var(MIC50): 4, MIC90: 16, RNG: (0.06–32)
    doripenem:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.015–0.25)
    ertapenem:  S(MIC50): 0.5, MIC90: 1, RNG: (0.015–1)
    imipenem:  S(MIC50): 0.03, MIC90: 0.125, RNG: (0.015–0.125)
    meropenem:  S(MIC50): 0.125, MIC90: 0.25, RNG: (0.015–0.25)
    gentamicin:  S(20; disc)
    kanamycin:  S(30; disc)
    neomycin:  S(30; disc)
    streptomycin:  S(30; disc)
    azithromycin:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    erythromycin:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)
    levofloxacin:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1)
    moxifloxacin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.06–0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    minocycline:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    tetracycline:  S(MIC50): 4, MIC90: 4, RNG: (0.125–4)
    vancomycin:  S(MIC50): 2, MIC90: 2, RNG: (0.125–2)
    chloramphenicol:  S(30; disc)
    sulfadimethoxine:  Res
    clindamycin:  R(MIC50): 2, MIC90: >64, RNG: (0.06–>64)
    daptomycin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–0.5)
    polymyxin_B:  S(100U)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM ACCOLENS
  • Nouioui2018 - Genome-Based Taxonomic Classification of the Phylum Actinobacteria.
  • Neubauer1991 - Corynebacterium accolens sp. nov., a Gram-Positive Rod Exhibiting Satellitism, from Clinical Material.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • Goldstein2008 - In vitro activities of doripenem and six comparator drugs against 423 aerobic and anaerobic bacterial isolates from infected diabetic foot wounds.
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM ACCOLENS
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Zeller2014 - Potential of fecal microbiota for early-stage detection of colorectal cancer
  • ...............................
    • GENERAL REFERENCES FOR CORYNEBACTERIUM ACCOLENS
  • Bilen2018e - Description of the human gut microbiota by culturomics
    • Added: January 05, 2022