Corynebacterium coyleae

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium coyleae is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, diphtheroidal bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. The DNA G+C content is 62-64%. Corynebacterium coyleae is probably a rare gut coloniser. (Funke1997; Bernard2012Bergey)



  • This organism has been recovered from human faeces and clinical sources (blood, wound, vagina - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. Is a known gut commensal.
    • QUIRKS
  • Nonlipophilic.
    • GENERAL CHARACTERISTICS (Funke1997); (Bernard2012Bergey);
    Character Response
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; mannose; ribose; 5-ketogluconate;
  • Active enzymes:
  • alkaline phosphatase; catalase; cystine arylamidase; esterase C4; esterase lipase C8; Leu arylamidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • pyrrolidine arylamidase;
    • SPECIAL FEATURES (Funke1997);
    Character Response
  • ✗
  • Metabolites not produced:
  • propionate;
  • ✗
  • VP test:
  • not active
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Funke1997);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; imipenem; oxacillin; penicillin G;
  • Cephalosporins:
  • cefuroxime; cephalothin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • linezolid;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Diphtheroidal
    Health:  Unknown
    Source:  human faeces and clinical sources (blood, wound, vagina - CCUG)
    DNA G+C(%):  62-64
    Mid T(℃):  37(+)
    		Aesculin:  neg Urea:  neg Gelatin:  neg Casein:  neg Tyrosine:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Arabinose:  neg D-Arabinose:  neg L-Arabinose:  neg Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  neg Glucose:  w Mannose:  + D-Lyxose:  neg Rhamnose:  neg Ribose:  + Sorbose:  neg D-Tagatose:  neg Xylose:  neg Cellubiose:  neg Gentiobiose:  neg Lactose:  neg Maltose:  neg Melezitose:  neg Melibiose:  neg Sucrose:  neg Trehalose:  neg Turanose:  neg Amygdalin:  neg Glycogen:  neg Inulin:  neg Starch:  neg Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Xylitol:  neg Arbutin:  neg Gluconate:  neg 2-Ketogluconate:  neg 5-Ketogluconate:  + Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg NAc-α-GA:  neg Salicin:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg OrnDC:  neg CystineAA:  + LeuAA:  + PyrrolidAA:  d ValAA:  neg AlkalineP:  + AcidP:  vr Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg Phosphoamidase:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Sens
    ampicillin:  Sens
    oxacillin:  Sens
    penicillin_G:  S(MIC50): 0.125, MIC90: 1, RNG: (0.125-1)
    imipenem:  Sens
    cefuroxime:  Sens
    cephalothin:  Sens
    gentamicin:  Sens
    erythromycin:  Var(MIC50): 0.06, MIC90: 64, RNG: (0.06-64)
    linezolid:  S(MIC50): 0.5, MIC90: 0.5, RNG: (2-25)
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    teicoplanin:  Sens
    vancomycin:  Sens
    rifampicin:  Sens
    chloramphenicol:  Sens
    clindamycin:  Var

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM COYLEAE
  • Funke1997 - Corynebacterium coyleae sp. nov., Isolated from Human Clinical Specimens.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM COYLEAE
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • Added: April 08, 2021