Corynebacterium durum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium durum is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, pleiomorph rod-shaped bacterium. It has been detected in at least 10 gut microbiome compilation studies or metastudies. The DNA G+C content is 55%. Corynebacterium durum is probably a common, although minor, coloniser of the gut. (Riegel1997; Bernard2012Bergey)



  • This organism has been recovered from human faeces and clinical sources (sputum, abscess, lesion - CCUT). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. Is a known gut commensal.
    • GENERAL CHARACTERISTICS (Riegel1997); (Bernard2012Bergey);
    Character Response
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; maltose; sucrose; mannitol;
  • Active enzymes:
  • catalase;
    • SPECIAL FEATURES (Riegel1997);
    Character Response
  • ✓
  • Metabolites produced:
  • propionate;
  • ✗
  • Metabolites not produced:
  • succinate;
  • ✓
  • Nitrate:
  • reduced
  • ✓
  • NO3➔NO2:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Riegel1997);
    Class Active Resistant
  • Penicillins:
  • amoxicillin-clavulanic acid; ampicillin; piperacillin;
  • Cephalosporins:
  • cefotaxime;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • minocycline;
  • Quinolines:
  • ciprofloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Vancomycins:
  • vancomycin; teicoplanin;

  • Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005). Diversity of the human intestinal microbial flora. Science (New York, N.Y.), 308(5728), 1635–1638.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Pleiomorph rod
    Health:  Unknown
    Source:  human faeces and clinical sources (sputum, abscess, lesion - CCUT)
    DNA G+C(%):  55
    		Aesculin:  w Urea:  w Gelatin:  neg Tyrosine:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  + Galactose:  + Glucose:  + Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  + Sucrose:  + Trehalose:  neg Glycogen:  neg Mannitol:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  vr β-Glucuronidase:  neg α-Mannosidase:  neg LeuAA:  neg PyrrolidAA:  neg AlkalineP:  neg AcidP:  vr Esterase(C4):  neg EstLip(C8):  vr Lipase(C14):  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Sens
    ampicillin:  Sens
    piperacillin:  Sens
    cefotaxime:  Sens
    gentamicin:  Sens
    erythromycin:  Sens
    ciprofloxacin:  Sens
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    minocycline:  Sens
    teicoplanin:  Sens
    vancomycin:  Sens
    rifampicin:  Sens

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM DURUM
  • Riegel1997 - Corynebacterium durum sp. nov., from Human Clinical Specimens.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • Jackson2016 - Signatures of early frailty in the gut microbiota
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM DURUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Cassir2015 - Clostridium butyricum Strains and Dysbiosis Linked to Necrotizing Enterocolitis in Preterm Neonates
  • De2020 - Metagenomic analysis of gut microbiome and resistome of diarrheal fecal samples from Kolkata, India, reveals the core and variable microbiota including signatures of microbial dark matter.
  • Jeong2021 - The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • Li2019b - Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus
  • McLaughlin2010 - The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing.
  • PerezBrocal2015 - Metagenomic Analysis of Crohn's Disease Patients Identifies Changes in the Virome and Microbiome Related to Disease Status and Therapy, and Detects Potential Interactions and Biomarkers
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021