Corynebacterium freneyi

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium freneyi is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, club-shaped-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. Corynebacterium freneyi is probably a rare gut coloniser. (Palacios2010; Renaud2001; Bernard2012Bergey)



  • This organism has been recovered from human faeces and clinical sources (cervix, vagina, wound, blood - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. It is an opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • Nonlipophilic.
    • GENERAL CHARACTERISTICS (Palacios2010); (Renaud2001); (Bernard2012Bergey);
    Character Response
  • 🌡
  • Temperature tolerance:
  • grows at 20℃; grows at 42℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; galactose; glucose; mannose; maltose; sucrose; trehalose; D-turanose; gluconate; 5-ketogluconate;
  • ±
  • Strain-dependent acid from carbs:
  • inulin; starch; cellubiose; arbutin;
  • ⥅
  • Substrates assimilated or utilised:
  • D-tagatose; succinate;
  • Active enzymes:
  • alkaline phosphatase; catalase; esterase C4; esterase lipase C8; α-glucosidase; Leu arylamidase; phosphoamidase;
  • ±
  • Strain-dependent active enzymes:
  • lipase C14;
    • SPECIAL FEATURES (Palacios2010); (Renaud2001);
    Character Response
  • ✓
  • VP test:
  • active
  • ±
  • Nitrate:
  • reduced by most strains
    • RESPONSE TO ANTIBIOTICS (Renaud2001);
    Class Active Resistant
  • Penicillins:
  • oxacillin; penicillin;
  • Macrolides:
  • pristinamycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • pefloxacin;
  • Aminoglycosides:
  • gentamicin; tobramycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • fusidic-acid; nitrofurantoin;
  • fosfomycin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • pristinamycin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Club rod
    Health:  Unknown
    Source:  human faeces and clinical sources (cervix, vagina, wound, blood - CCUG)
    Lower T(℃):  20(+)
    High T(℃):  42(+)
    		Aesculin:  neg Urea:  neg Gelatin:  neg Hippurate:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    D-Arabinose:  neg L-Arabinose:  neg Fructose:  + Fucose:  neg D-Fucose:  neg Galactose:  + Glucose:  + Mannose:  d(+) D-Lyxose:  neg Rhamnose:  neg Ribose:  w Sorbose:  neg D-Tagatose:  neg Xylose:  neg Cellubiose:  d(neg) Gentiobiose:  neg Lactose:  neg Maltose:  + Melezitose:  neg Melibiose:  neg Sucrose:  + Trehalose:  + Turanose:  d(+) Amygdalin:  neg Dextrin:  neg Glycogen:  neg Inulin:  d Starch:  d(neg) Adonitol:  neg D-Arabitol:  neg L-Arabitol:  neg Dulcitol:  neg Erythritol:  neg Glycerol:  neg Mannitol:  neg Sorbitol:  neg Arbutin:  d(neg) Gluconate:  d(+) 2-Ketogluconate:  neg 5-Ketogluconate:  d(+) Me-α-D-Glc:  neg Me-α-D-Mann:  neg Me-Xyloside:  neg Salicin:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    D-Tagatose:  + Asp:  neg His:  neg Lactate:  neg Succinate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  neg Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  d(+) β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg β-Mannosidase:  neg ArgDH:  neg Chymotrypsin:  neg Trypsin:  neg AlaPheProAA:  neg CystineAA:  neg LeuAA:  + PyrrolidAA:  neg ValAA:  neg AlkalineP:  + AcidP:  neg Esterase(C4):  d(+) EstLip(C8):  + Lipase(C14):  d Phosphoamidase:  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    oxacillin:  Sens
    penicillin:  Sens
    gentamicin:  Sens
    tobramycin:  Sens
    erythromycin:  Var
    pristinamycin:  Sens
    pefloxacin:  S(vr)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  Sens
    vancomycin:  Sens
    rifampicin:  S(vr)
    fosfomycin:  Res
    nitrofurantoin:  S(vr)
    fusidic-acid:  Sens

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM FRENEYI
  • Palacios2010 - Characterization of Some Bacterial Strains Isolated from Animal Clinical Materials and Identified as Corynebacterium xerosis by Molecular Biological Techniques.
  • Renaud2001 - Corynebacterium freneyi sp. nov., alpha-glucosidase-positive strains related to Corynebacterium xerosis.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM FRENEYI
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • Added: April 08, 2021