Corynebacterium lipophiloflavum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium lipophiloflavum is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, club-shaped-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 65%. Corynebacterium lipophiloflavum is probably a rare gut coloniser. (Funke1997b; Bernard2012Bergey)



  • This organism has been recovered from clinical specimens (vaginosis). The risk classification (www.baua.de) for this organism is 1, i.e., low risk of infection and spread (notes: opportunistic in immunocompromised patients). It is an opportunistic pathogen. A possible gut commensal.
    • QUIRKS
  • Slightly lipophilic.
    • GENERAL CHARACTERISTICS (Funke1997b); (Bernard2012Bergey);
    Character Response
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; catalase; esterase C4; esterase lipase C8; Leu arylamidase; lipase C14; phosphoamidase;
    • SPECIAL FEATURES (Funke1997b);
    Character Response
  • ✗
  • Nitrate:
  • not reduced
  • Pigments:
  • yellow
    • RESPONSE TO ANTIBIOTICS (Funke1997b);
    Class Active Resistant
  • Penicillins:
  • amoxicillin; amoxicillin-clavulanic acid; imipenem; meropenem; oxacillin; penicillin;
  • aztreonam;
  • Cephalosporins:
  • cefazolin; cefuroxime;
  • Macrolides:
  • azithromycin; clarithromycin; erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin; norfloxacin; sparfloxacin;
  • Aminoglycosides:
  • amikacin; gentamicin; netilmycin; tobramycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol; fusidic-acid;
  • fosfomycin;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Club rod Pigment:  yellow
    Health:  Unknown
    Source:  clinical specimens (vaginosis)
    DNA G+C(%):  65
    		Aesculin:  neg Urea:  w
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Glucose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg Glycogen:  neg Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg Chymotrypsin:  neg Trypsin:  neg CystineAA:  neg LeuAA:  + PyrrolidAA:  neg ValAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  + Phosphoamidase:  +
    METABOLITES - PRODUCTION & USE
    Fuel Usable Metabolites Metabolites Released Special Products Compounds Produced

    		Pigment:  yellow
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    amoxicillin:  S(0.25)
    Augmentin:  S(0.063)
    aztreonam:  R(>64)
    oxacillin:  S(1)
    penicillin:  S(0.125)
    imipenem:  S(0.063)
    meropenem:  S(0.25)
    cefazolin:  S(<0.125)
    cefuroxime:  S(0.5)
    amikacin:  S(1)
    gentamicin:  S(0.125)
    netilmycin:  S(0.125)
    tobramycin:  S(0.125)
    azithromycin:  S(0.063)
    erythromycin:  S(0.03)
    clarithromycin:  S(<0.03)
    ciprofloxacin:  S(0.25)
    norfloxacin:  S(2)
    sparfloxacin:  S(0.25)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(2)
    teicoplanin:  S(0.5)
    vancomycin:  S(0.5)
    rifampicin:  S(0.063)
    chloramphenicol:  S(2)
    fosfomycin:  R(>256)
    clindamycin:  S(0.125)
    fusidic-acid:  S(0.125)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM LIPOPHILOFLAVUM
  • Funke1997b - Corynebacterium lipophiloflavum sp. nov. isolated from a patient with bacterial vaginosis.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM LIPOPHILOFLAVUM
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • ...............................
    • Added: January 14, 2022