Corynebacterium propinquum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium propinquum is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 4 gut microbiome compilation studies or metastudies. The DNA G+C content is 57-59%. Corynebacterium propinquum is probably a rare gut coloniser. (Bernard2013; Riegel1993a; Bernard2012Bergey)



  • This organism has been recovered from clinical sources (wound, repiratory tract - CCUG) and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a rare opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Bernard2013); (Riegel1993a); (Bernard2012Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • tyrosine;
  • 🧂
  • Salt tolerance:
  • tolerates 6.5% salt;
  • 🌡
  • Temperature tolerance:
  • grows at 25℃; grows at 37℃; doesn't grow at 45℃;
  • ⥅
  • Substrates assimilated or utilised:
  • acetate; lactate; malate;
  • Active enzymes:
  • acid phosphatase; catalase; esterase C4; esterase lipase C8; Leu arylamidase;
  • ±
  • Strain-dependent active enzymes:
  • urease;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Methyl red test:
  • not active
  • ✗
  • VP test:
  • not active
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
  • ✓
  • NO3➔NO2:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Bernard2013); (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • ertapenem; meropenem; penicillin; penicillin G;
  • Cephalosporins:
  • cefepime; cefotaxime; cefuroxime;
  • Macrolides:
  • azithromycin; erythromycin; quinupristin-dalfopristin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline; tigecycline;
  • Quinolines:
  • ciprofloxacin; levofloxacin; moxifloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

  • Lagier, J.-C., Armougom, F., Million, M., Hugon, P., Pagnier, I., Robert, C., Bittar, F., Fournous, G., Gimenez, G., Maraninchi, M., Trape, J.-F., Koonin, E. V., La Scola, B., & Raoult, D. (2012). Microbial culturomics: paradigm shift in the human gut microbiome study. Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(12), 1185–1193.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  clinical sources (wound, repiratory tract - CCUG) and human faeces
    DNA G+C(%):  57-59
    Lower T(℃):  25(+)
    Mid T(℃):  37(+)
    High T(℃):  45(neg)
    NaCl >6%:  6.5(+)
    		Aesculin:  neg Urea:  vr Gelatin:  neg Starch:  neg Tyrosine:  + Hippurate:  vr
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Galactose:  neg Glucose:  neg Mannose:  neg Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Trehalose:  neg Glycogen:  neg Mannitol:  neg
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  neg Fructose:  neg Glucose:  neg Mannose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Sucrose:  neg N_Acetyl_glucosamine:  neg Mannitol:  neg Acetate:  + Adipate:  vr Caprate:  neg Citrate:  neg Lactate:  + Malate:  + Phenylacetate:  vr Propionate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Urease:  d Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg LeuAA:  + PyrrolidAA:  vr AlkalineP:  vr AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Var(MIC50): 1, MIC90: 2
    penicillin:  SensRNG: (<0.03-0.12)
    penicillin_G:  S(MIC50): 1, MIC90: 1, RNG: (0.125–1)
    ertapenem:  S(0.5)
    meropenem:  S(0.25)
    cefepime:  S(0.05)
    cefotaxime:  S(0.12)
    cefuroxime:  S(0.5)
    gentamicin:  S(2)
    azithromycin:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    erythromycin:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    quin-dalf:  SensRNG: (0.12-0.5)
    linezolid:  SensRNG: (0.25-1)
    ciprofloxacin:  SensRNG: (0.5->2,vr)
    levofloxacin:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1)
    moxifloxacin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.06–0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    minocycline:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    tetracycline:  S(MIC50): 4, MIC90: 4, RNG: (0.125–4)
    tigecycline:  SensRNG: (0.03-0.12)
    vancomycin:  S(MIC50): 2, MIC90: 2, RNG: (0.125–2)
    rifampicin:  S(0.5)
    chloramphenicol:  Var(MIC50): 2->32), MIC90: Var(2->32
    SXT:  S(MIC50): 0.5, MIC90: 9.5, RNG: (<0.5->76)
    clindamycin:  R(0.12->2,vr)
    daptomycin:  SensRNG: (0.006-0.5)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM PROPINQUUM
  • Bernard2013 - Emendation of the description of the species Corynebacterium propinquum to include strains which produce urease.
  • Riegel1993a - Proposal of Corynebacterium propinquum sp. nov. for Corynebacterium group ANF-3 strains.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM PROPINQUUM
  • Byrd2020 - Stability and dynamics of the human gut microbiome and its association with systemic immune traits.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • Added: April 08, 2021