Corynebacterium pseudodiphtheriticum

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium pseudodiphtheriticum is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, club-shaped-shaped bacterium. It has been detected in at least 3 gut microbiome compilation studies or metastudies. The DNA G+C content is 54.9-56.8%. Corynebacterium pseudodiphtheriticum is probably a rare gut coloniser. (Bernard2012Bergey)



  • This organism has been recovered from human faeces and clinical sources (blood, sputum, wound - CCUG). The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread. Is a rare opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Bernard2012Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • hippurate; urea;
  • 🌡
  • Temperature tolerance:
  • Grows optimally at 37℃.
  • Active enzymes:
  • catalase; urease;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Metabolites not produced:
  • propionate;
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Bernard2013a); (González2006);
    Class Active Resistant
  • Penicillins:
  • ertapenem; meropenem; penicillin;
  • Cephalosporins:
  • cefepime; cefotaxime; cefuroxime;
  • Macrolides:
  • clarithromycin; quinupristin-dalfopristin;
  • erythromycin;
  • Tetracyclines:
  • doxycycline; tetracycline; tigecycline;
  • Quinolines:
  • ciprofloxacin; levofloxacin; moxifloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol; trimethoprim-sulfamethoxazole;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

  • Drasar, BS & MJ Hill (1974). Composition of the gut flora. Human intestinal flora. Vol. (BS Drasar and MJ Hill, eds.), pp. 26-35 Academic Press Inc. Ltd., London.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Club rod
    Health:  Unknown
    Source:  human faeces and clinical sources (blood, sputum, wound - CCUG)
    DNA G+C(%):  54.9-56.8
    Opt. T:  37℃
    		Urea:  + Hippurate:  +
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  + Phosphoamidase:  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    Augmentin:  Var(MIC50): 1, MIC90: 2
    ampicillin:  Var(MIC50): 0.5, MIC90: 32, RNG: (0.03–>32)
    penicillin:  SensRNG: (<0.03-0.12)
    piper-taz:  Var(MIC50): 4, MIC90: 32, RNG: (0.03–>128)
    ertapenem:  S(0.5)
    imipenem:  Var(MIC50): 0.04, MIC90: 32, RNG: (0.03–>32)
    meropenem:  S(0.25)
    cefepime:  S(0.05)
    cefotaxime:  S(0.12)
    cefuroxime:  S(0.5)
    gentamicin:  S(2)
    azithromycin:  Var(MIC50): ≤0.015->128), MIC90: Var(≤0.015->128
    erythromycin:  R(0.25->4,vr)
    clarithromycin:  SensRNG: (≤0.015-4)
    quin-dalf:  S(MIC50): 0.5, MIC90: 0.5, RNG: (0.125-2)
    roxithromycin:  Var(MIC50): ≤0.015-16), MIC90: Var(≤0.015-16
    linezolid:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125-0.5)
    ciprofloxacin:  S(0.5)
    levofloxacin:  SensRNG: (0.25-1)
    moxifloxacin:  S(1)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  SensRNG: (0.12-0.25)
    tetracycline:  SensRNG: (1-2)
    tigecycline:  S(0.12)
    vancomycin:  SensRNG: (0.05-1)
    rifampicin:  S(0.5)
    chloramphenicol:  SensRNG: (2-4)
    SXT:  S(MIC50): 0.5, MIC90: 9.5, RNG: (<0.5->76)
    clindamycin:  R(0.12->2,vr)
    daptomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.125-0.5)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM PSEUDODIPHTHERITICUM
  • Nouioui2018 - Genome-Based Taxonomic Classification of the Phylum Actinobacteria.
  • Bernard2013a - Emendation of the description of the species Corynebacterium propinquum to include strains which produce urease.
  • González2006 - Neumonia por Corynebacterium pseudodiphteriticum: una patologia a considerar [Pneumonia by Corynebacterium pseudodiphteriticum: an infection to consider].
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM PSEUDODIPHTHERITICUM
  • Forster2019 - A human gut bacterial genome and culture collection for improved metagenomic analyses.
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
  • ...............................
    • Added: April 08, 2021