Corynebacterium pseudogenitalium

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium pseudogenitalium is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, pleiomorph rod-shaped bacterium. It has been detected in at least 2 gut microbiome compilation studies or metastudies. Corynebacterium pseudogenitalium is probably a rare gut coloniser. (Vedel2006; Evangelista1984)



  • This organism has been recovered from the normal flora of the genitourinary tract. Is a rare opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Vedel2006); (Evangelista1984);
    Character Response
  • ±
  • Strain-dependent hydrolysis or digestion:
  • urea;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; ribose; maltose;
  • ±
  • Strain-dependent acid from carbs:
  • glucose; sucrose;
  • Active enzymes:
  • catalase; oxidase; urease;
  • ±
  • Strain-dependent active enzymes:
  • lipase;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Haemolysis:
  • absent
  • ✓
  • Nitrate:
  • reduced
    • RESPONSE TO ANTIBIOTICS (Vedel2006); (Evangelista1984); (Tyrrell2012);
    Class Active Resistant
  • Penicillins:
  • ampicillin; carbenicillin; methicillin; penicillin G; piperacillin-tazobactam;
  • Cephalosporins:
  • cephalothin;
  • Macrolides:
  • erythromycin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin; norfloxacin;
  • Aminoglycosides:
  • gentamicin; kanamycin; streptomycin; tobramycin;
  • Polypep/ketides:
  • rifampicin;
  • Heterocycles:
  • chloramphenicol; sulfadiazine; sulfamethoxazole; trimethoprim;
  • nitrofurantoin;
  • Vancomycins:
  • vancomycin; teicoplanin;
  • Miscellaneous antibiotics:
  • clindamycin; daptomycin; linezolid; polymyxin B;
  • lincomycin;

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Pleiomorph rod
    Health:  Unknown
    Source:  the normal flora of the genitourinary tract
    		Aesculin:  neg Urea:  d(neg) Gelatin:  neg
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  + Glucose:  d Ribose:  + Maltose:  + Sucrose:  d
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  + Catalase:  + Urease:  + Lipase:  d(w)
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 1, MIC90: >32, RNG: (0.03–32)
    carbenicil:  S(100; disc)
    methicillin:  S(5; disc)
    penicillin_G:  S(10U)
    piper-taz:  S(MIC50): 4, MIC90: >128, RNG: (0.03->128)
    imipenem:  Var(MIC50): 0.06, MIC90: >32, RNG: (0.03->32)
    cephalothin:  S(30; disc)
    gentamicin:  S(10; disc)
    kanamycin:  S(30; disc)
    streptomycin:  S(10; disc)
    tobramycin:  S(10; disc)
    erythromycin:  Res
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)
    ciprofloxacin:  Sens
    norfloxacin:  S(clinic)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(30; disc)
    teicoplanin:  Sens
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.25–1)
    rifampicin:  Sens
    chloramphenicol:  S(30; disc)
    nitrofurantoin:  Res
    sulfadiazine:  S(1000; disc)
    sulfamethoxazole:  Sens
    trimethoprim:  Sens
    clindamycin:  S(2; disc)
    lincomycin:  Res
    daptomycin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–0.5)
    polymyxin_B:  S(300U)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM PSEUDOGENITALIUM
  • Vedel2006 - Corynebacterium pseudogenitalium urinary tract infection.
  • Evangelista1984 - Relationship between group JK corynebacteria and the biotypes of Corynebacterium genitalium and Corynebacterium pseudogenitalium.
  • JaenLuchoro2022 - Corynebacterium genitalium sp. nov., nom. rev. and Corynebacterium pseudogenitalium sp. nov., nom. rev., two old species of the genus Corynebacterium described from clinical and environmental samples.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
  • ...............................
    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM PSEUDOGENITALIUM
  • Lagier2016 - Culture of previously uncultured members of the human gut microbiota by culturomics.
  • ...............................
    • Added: February 09, 2022