Corynebacterium sanguinis

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium sanguinis is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 65%. Corynebacterium sanguinis is probably a rare gut coloniser. (JaenLuchoro2020)



  • This organism has been recovered from clinical sources (blood, wound - CCUG) and human faeces. It is an opportunistic pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (JaenLuchoro2020);
    Character Response
  • Substrates hydrolysed or digested:
  • hippurate; urea;
  • 🧂
  • Salt tolerance:
  • tolerates 5% salt; strain-variable at 7.5(d)%;
  • 🌡
  • Temperature tolerance:
  • grows at 36℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose;
  • Active enzymes:
  • alkaline phosphatase; catalase; esterase lipase C8; Leu arylamidase; lipase C14; urease;
  • ±
  • Strain-dependent active enzymes:
  • acid phosphatase;
    • SPECIAL FEATURES
    Character Response
  • ✗
  • Nitrate:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (JaenLuchoro2020); (Tyrrell2012);
    Class Active Resistant
  • Penicillins:
  • ampicillin; piperacillin-tazobactam;
  • benzylpenicillin;
  • Tetracyclines:
  • tetracycline;
  • Quinolines:
  • ciprofloxacin; moxifloxacin;
  • Aminoglycosides:
  • gentamicin;
  • Polypep/ketides:
  • rifampicin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • daptomycin; linezolid;
  • clindamycin;

  • Manichanh, C., Chapple, C. E., Frangeul, L., Gloux, K., Guigo, R., & Dore, J. (2008). A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library. Nucleic Acids Research, 36(16), 5180–5188.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Rod
    Health:  Unknown
    Source:  clinical sources (blood, wound - CCUG) and human faeces
    DNA G+C(%):  65
    Mid T(℃):  36(+)
    NaCl 3-5%:  5(+)
    NaCl >6%:  7.5(d)
    		Aesculin:  neg Urea:  + Gelatin:  neg Starch:  neg Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  d(+) Glucose:  + Ribose:  neg Xylose:  neg Lactose:  neg Maltose:  neg Glycogen:  neg Mannitol:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Catalase:  + Urease:  + Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  neg β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg LeuAA:  + PyrrolidAA:  neg AlkalineP:  + AcidP:  d(neg) Esterase(C4):  vr EstLip(C8):  + Lipase(C14):  +
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    ampicillin:  S(MIC50): 1, MIC90: >32, RNG: (0.03–32)
    benzyl-pen:  R(1U)
    piper-taz:  S(MIC50): 4, MIC90: >128, RNG: (0.03->128)
    imipenem:  Var(MIC50): 0.06, MIC90: >32, RNG: (0.03->32)
    gentamicin:  S(10; disc)
    linezolid:  S(MIC50): 0.5, MIC90: 1, RNG: (0.25–1)
    ciprofloxacin:  S(5; disc)
    moxifloxacin:  S(5; disc)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    tetracycline:  S(30; disc)
    vancomycin:  S(MIC50): 0.25, MIC90: 0.5, RNG: (0.25–1)
    rifampicin:  S(5; disc)
    clindamycin:  R(2; disc, variable)
    daptomycin:  S(MIC50): 0.06, MIC90: 0.25, RNG: (0.03–0.5)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM SANGUINIS
  • JaenLuchoro2020 - Corynebacterium sanguinis sp. nov., a clinical and environmental associated corynebacterium.
  • Tyrrell2012 - In vitro activity of TD-1792, a multivalent glycopeptide-cephalosporin antibiotic, against 377 strains of anaerobic bacteria and 34 strains of Corynebacterium species.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM SANGUINIS
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021