Corynebacterium ulcerans

Bacteria
General | Carbohydrate O/F | Substrate utilisation | Enzymes | Metabolites | Antibiotics

Overview

  • Corynebacterium ulcerans is a Gram-positive, non-spore-forming, facultatively anaerobic, non-motile, pleiomorph rod-shaped bacterium. It has been detected in at least 1 gut microbiome compilation study or metastudy. The DNA G+C content is 53-55%. Corynebacterium ulcerans is probably a rare gut coloniser. (Riegel1995a; Bernard2012Bergey)



  • This organism has been recovered from clinical sources (throat, wound, sinus - CCUG) and human faeces. The risk classification (www.baua.de) for this organism is 2, i.e., risk of individual infection, but low risk of spread (notes: human and animal pathogen). Is a known human pathogen. A possible gut commensal.
    • GENERAL CHARACTERISTICS (Riegel1995a); (Bernard2012Bergey);
    Character Response
  • Substrates hydrolysed or digested:
  • DNA; hippurate; starch; urea;
  • ±
  • Strain-dependent hydrolysis or digestion:
  • gelatin;
  • 🧂
  • Salt tolerance:
  • strain-variable at 6.5(d)%;
  • 🌡
  • Temperature tolerance:
  • grows at 37℃;
  • H+
  • Acid from carbohydrates usually produced:
  • fructose; glucose; ribose; glycogen; maltose;
  • ±
  • Strain-dependent acid from carbs:
  • mannitol;
  • ⥅
  • Substrates assimilated or utilised:
  • arabinose; glucose; maltose; mannose; malate;
  • ±
  • Strain-dependent substrate utilisation:
  • gluconate; mannitol;
  • Active enzymes:
  • alkaline phosphatase; acid phosphatase; catalase; esterase C4; esterase lipase C8; α-glucosidase; Leu arylamidase;
    • SPECIAL FEATURES (Riegel1995a);
    Character Response
  • ✓
  • Metabolites produced:
  • propionate;
  • ✗
  • VP test:
  • not active
  • Haemolysis:
  • present but weak
  • ✗
  • Nitrate:
  • not reduced
  • ✗
  • NO3➔NO2:
  • not reduced
    • RESPONSE TO ANTIBIOTICS (Goldstein2000);
    Class Active Resistant
  • Penicillins:
  • penicillin G;
  • Macrolides:
  • azithromycin; erythromycin;
  • Tetracyclines:
  • doxycycline; minocycline; tetracycline;
  • Quinolines:
  • levofloxacin; moxifloxacin;
  • Vancomycins:
  • vancomycin;
  • Miscellaneous antibiotics:
  • linezolid;

  • Drasar, BS & MJ Hill (1974). Composition of the gut flora. Human intestinal flora. Vol. (BS Drasar and MJ Hill, eds.), pp. 26-35 Academic Press Inc. Ltd., London.

    • Details

    GENERAL
    Lineage Physiology General Growth Tolerances Hydrol./digest./degr.
    Phylum:  Actinobacteria Class:  Actinomycetia Order:  Corynebacteriales Family:  Corynebacteriaceae Genus:  Corynebacterium Gram stain:  + O2 Relation.:  facultatively anaerobic Spore:  No spore Motility:  Sessile Morphology:  Pleiomorph rod
    Health:  Unknown
    Source:  clinical sources (throat, wound, sinus - CCUG) and human faeces
    DNA G+C(%):  53-55
    Mid T(℃):  37(+)
    NaCl >6%:  6.5(d)
    		Aesculin:  neg Urea:  + Gelatin:  d Starch:  + DNA:  + Tyrosine:  neg Hippurate:  +
    CARBOHYDRATE ACID FORMATION
    Monosaccharide O/F Oligosaccharide O/F Polysaccharide O/F Polyol O/F Other O/F
    Fructose:  + Glucose:  + Ribose:  + Xylose:  neg Lactose:  neg Maltose:  + Sucrose:  neg Glycogen:  + Mannitol:  d
    SUBSTRATE ASSIMILATION & UTILISATION
    Monosaccharide util/assim Oligosaccharide util/assim Other carboh. util/assim Amino acid util/assim Organic acid util/assim
    Arabinose:  + Glucose:  + Mannose:  + Maltose:  + Gluconate:  d Mannitol:  d Acetate:  neg Adipate:  neg Caprate:  neg Lactate:  neg Malate:  + Phenylacetate:  neg Propionate:  neg
    ENZYME ACTIVITY
    Enzymes: General Enzymes: Carbohydrate Enzymes: Protein Enzymes: Arylamidases Enzymes: Esters/fats
    Oxidase:  neg Catalase:  + Ac-β-glcamnd:  neg α-Fucosidase:  neg α-Galactosidase:  neg β-Galactosidase:  neg α-Glucosidase:  + β-Glucosidase:  neg β-Glucuronidase:  neg α-Mannosidase:  neg LeuAA:  + PyrrolidAA:  neg AlkalineP:  + AcidP:  + Esterase(C4):  + EstLip(C8):  + Lipase(C14):  neg
    ANTIBIOTICS ℞
    Penicillins & Penems (μg/mL) Cephalosporins (μg/mL) Aminoglycosides (μg/mL) Macrolides (μg/mL) Quinolones (μg/mL)
    penicillin_G:  S(MIC50): 0.12, MIC90: 0.25, RNG: (0.12-0.25)
    azithromycin:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    erythromycin:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    linezolid:  S(MIC50): 0.25, MIC90: 0.5, (0.25-1)
    levofloxacin:  S(MIC50): 1, MIC90: 1, RNG: (0.5–1)
    moxifloxacin:  S(MIC50): 0.25, MIC90: 0.25, RNG: (0.06–0.5)
    Tetracyclines (μg/mL) Vancomycin Class (μg/mL) Polypep/ketides (μg/mL) Heterocycles (μg/mL) Other (μg/mL)
    doxycycline:  S(MIC50): 0.125, MIC90: 0.125, RNG: (0.125–0.25)
    minocycline:  S(MIC50): 0.03, MIC90: 0.06, RNG: (0.03–0.125)
    tetracycline:  S(MIC50): 4, MIC90: 4, RNG: (0.125–4)
    vancomycin:  S(MIC50): 2, MIC90: 2, RNG: (0.125–2)

    References

    SPECIFIC REFERENCES FOR CORYNEBACTERIUM ULCERANS
  • Riegel1995a - Taxonomy of Corynebacterium diphtheriae and related taxa, with recognition of Corynebacterium ulcerans sp. nov. nom. rev.
  • Bernard2012Bergey - Bergey's manual of systematic bacteriology. Vol. 5, The Actinobacteria. Part A & B. Corynebacteriaceae, Genus I. Corynebacterium
  • Goldstein2000 - Comparative in vitro activities of GAR-936 against aerobic and anaerobic animal and human bite wound pathogens.
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    • GUT MICROBIOME COMPILATIONS AND METASTUDIES FOR CORYNEBACTERIUM ULCERANS
  • RajilicStojanovic2014 - The first 1000 cultured species of the human gastrointestinal microbiota.
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    • Added: April 08, 2021